Demonstrates a Prolonged Release of CBD in Large Animals Herzliya, Israel and Calgary, Alberta--(Newsfile Corp. - September 3, 2021) - Innocan Pharma Corporation (CSE: INNO) (FSE: IP4) (OTCQB: INNPF) (the "Company" or "Innocan"), is pleased to announce that it has conducted a recent experimental study of its CBD-loaded liposome technology (LPT) on large animals that demonstrated a similar pharmacokinetic profile as was demonstrated in a previous small animal study. This result is expected to bring the Company closer to clinical trials in humans.
Pharmacokinetics (PK) determines the profile of drug concentrations in the blood as a function of time from the moment that it was administered thus indicating drug efficacy.
Prolonged release of Cannabidiol (CBD) from the Liposomes injected subcutaneously to a large animal showed continuous blood concentrations of CBD over a long time. Similar to what was found previously in small animals studies and is considered a good predictor to the expected exposure in humans. The data obtained suggests that Innocan's LPT platform may be suitable for human therapeutic applications.
The continuous exposure to CBD-in blood for a long time post local administration, seems to be superior to orally administered CBD in two aspects: it will all allow a single administration instead of daily administration and it will overcome- the low (10-20%) oral bioavailability of CBD. The superior PK of the CBD in LPT may enable to achieve controlled concentration of CBD in the blood leading to a better clinical outcome.
https://www.newsfilecorp.com/release/95564/Innocan-Pharmas-CBDLoaded-Liposome-Platform-Technology-Demonstrates-a-Prolonged-Release-of-CBD-in-Large-Animals