Barring external factors (which I still think are the real cause) the below would point to some characteristic of 346 that is not dose dependent but that takes 3+ weeks to manifest elevated LTEs regardless of dose size. Seems counter-intuitive and unlikely but, sigh, not out of the realm of possibility until they finalize the investigation.


MrMugsy wrote: Not much to say until we hear back.

In Phase 2 those on 200 mg dose consumed 2800 mg in total (over 14 days).
Now, at 100 mg dose, they consumed 2800 mg over a 28 day period.
Something doesn't make sense - what's at play ?

Waiting for some understanding.