RE:MCNA didn't fail...the design of the trial did.I really think that corruption such as has been reported by the Wash Post had a major effect on TST approval. It is very difficult in the USA to make headway without lobbyists. To my knowledge TST did not use lobbyists. Courts have proven that big pharma control the FDA both by altering trial designs such as not accounting for patients who drop out early or buying off panel scientists at the highest level which is a small price to pay for a billion $$ drug. This is a sad sad situation. FDA approved drugs today offer no more insurance of efficacy or safety than those reaching the market via testimonials.