TSXV:CLAS.H - Post by User
Comment by
MyKnighton Feb 11, 2020 11:19am
124 Views
Post# 30674053
RE:RE:Urgent Question for Kalytera Management
RE:RE:Urgent Question for Kalytera ManagementGood reading, and we also have an exceptional one in GVHD,
RE:Urgent Question for Kalytera Management
There’s many reasons why a companies choose to do randomized and/or non randomized. This below, sounds like a Kalytera to me. But I could be wrong.
3. Nonrandomized studies are usually less expensive. An advantage of nonrandomized studies is that they usually cost less per subject and may not require the extensive planning and control that are needed for randomized studies. This makes nonrandomized studies particularly attractive in the early stages of any research effort. Preliminary estimates of the relative importance of many background variables and their variation may be developed at a rea- sonable cost. These data may be important in designing future randomized ex- periments.
Also, if the investigator is expecting or is interested only in very large, "slam-bang" effects(Gilbertetal.,1975),nonrandomizedstudiesmaydetect such differences adequately. For instance, the effect of penicillin on mortality was so obvious when it was first used that no randomized study was necessary. However, Gilbert et al. (1975, 1977), after reviewing a large number of inno- vations in social and medical areas evaluated by randomized and nonrandomized studies, conclude that such slam-bang effects are exceptional.