Claritas Pharmaceuticals Inc V.CLAS.H

Nitric Oxide & its inherent Covid-19 killing strategy

[PowerofNow]

Dude51 wrote: Data from rodent study are strongly positive

Salzman Group studied the effectiveness of R-107 in a rodent model that is very severe and is designed to mimic life-threatening COVID-19 infection. It is characterized by a 90-per-cent mortality rate within seven days, with development of tissue injury in the lung, kidney, pancreas, intestine and liver. This model correlates closely with the human clinical presentation of circulatory shock and multiple organ failure, and thus has served for many decades as a key benchmark in the initial assessment of novel candidate therapeutics for treatment of human sepsis and circulatory shock.

Results from this study were strongly positive, with the active moiety of R-107 demonstrating increased survival from 10 per cent to 90 per cent in septic mice over a week of follow-up. This extraordinary improvement in survival was reflected in the results of blood tests and microscopy showing full tissue protection in all the organs examined, including the liver, lung and small intestine.

The study was conducted by Professor Salvatore Cuzzocrea, president of the University of Messina, and former president of the European Shock Society. A sepsis-like syndrome was created in mice by inoculation with bacterial endotoxin, thereby producing a massive release of pro-inflammatory signalling molecules (cytokines) such as interleukin-1 beta and tumour necrosis factor alpha, which together are able to trigger the full hemodynamic, hematologic and immunologic manifestations typical of the lethal human circulatory shock caused by COVID-19 infection.