NASH patients die of CVDThe hardest endpoint in medicine is death.
A wise, leading hepatologist told me that his biggest concern with his NASH patients was them dying of CVD.
Think of the TH news release with regards to systemic inflammation and CVD risk. This is not 'tangential' science.
"The mechanisms by which NAFLD increases CV risk are very complex and involve simultaneously different pathways at different functional and structural levels, namely the metabolism, cardiovascular system, and liver function. Insulin resistance is recognized as the main determinant of NAFLD pathogenesis but as to how NAFLD is responsible for accelerated atherosclerosis, independently of metabolic abnormalities, remains unclear. Probably, the hepatic necro-inflammation with the consequent systemic diffusion of cytokines and chemokines leads to vascular damage and coagulation system abnormalities. It is also possible that NAFLD and CV diseases share a common inherited predisposition, which further influences the CV risk in these patients."