GREY:ATBPF - Post by User
Comment by
bringon10baggeron Mar 25, 2021 1:24pm
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Post# 32876287
RE:RE:Expensive Pfizer drug for OA likely to fail
RE:RE:Expensive Pfizer drug for OA likely to failThat's welcoming to understand the FDA and their positioning for improvement in treatment over existing NSAID, and knowing the qualities of ATB-346 over existing NSAID things look very encouraging....SUPER GI Safe over existing, smaller dosing for better WOMAC results and could be less than already established and notthing else any worse than existing NSAID's. THAT'S ENCOURAGING.........
Straylight wrote: Nice article. Couple good quotes about that drug from the link:
"Although FDA said tanezumab proved to be effective, its effect size “is modest, and there is no convincing evidence of a superior efficacy of tanezumab over NSAIDs.”
"In addition, the agency said tanezumab is associated with an elevated risk of requiring a total joint replacement, as observed in two of the three post-2015 clinical studies, with evidence of dose response. There is also evidence that the risk for developing joint destruction is 2- to 3-fold higher if NSAIDs and tanezumab are used together, FDA said."