RE:The Panc cancer results are very good! Not sure if "modest" = very good or not. I kind of suspect this management team be dishonest, i.e., cherry picking to release the results.
"
The combination of pelareorep and pembrolizumab showed a manageable safety profile and modest efficacy in an unselected PDAC population. Additional correlation analyses between treatment efficacy and immunological changes will be presented. The anti-tumor activity of pelareorep and checkpoint blockade therapy is being evaluated further in additional ongoing studies." "
Thirteen patients were enrolled. Disease control was achieved in 33% of the 12 efficacy-evaluable patients. One patient achieved a partial response (PR). Three additional patients achieved stable disease (SD). On-treatment tumor biopsies, collected during C1, showed pelareorep replication, increased infiltration of CD8+ T cells and PD-L1+ cells, and decreased expression of VDAC1, a mitochondrial gatekeeper for tumor promotion, relative to archival tissue. Reduced infiltration of Foxp3+ regulatory T cells (Treg) was observed in patients showing tumor response. Peripheral blood was collected at day 1 of each cycle and on C1 day 8. Relative to pretreatment samples, the number of CD8+ effector memory T cells and B cells tend to increase while the number of Treg cells declined in C2 onwards in patients with tumor response. Furthermore, these patients had increased expression of the mitochondrial protein TOMM20 in CD8+ T cells and decreased expression of PD-1 and the H3K27me3 epigenetic mark in Treg. Treatment was well tolerated with most treatment-related adverse events, including flu-like symptoms, being grade 1 or 2." canadafan wrote: The Panc cancer results are very good.
Panc cancer is almost untreatable. They showed moderate efficacy....that is great.
add that on- top- of , most recent Car-t results " complete cure" and Mbc & a bio marker
they have good reason to be somewhat arrogant, with the future.
enough $ to last 1.5 yrs & about 3 major announcements within next 6 months.
The Car-t partnership will be early ( my prediction) this fall.
moving SP into a reasonable range, to negotiate the phase 3 deal.
lots of irons in the fire & the SP does not come even close to reflecting that.