RE:RE:RE:RE:Dr. Lilge OSA Webinar - Aug. 18 I'm glad Dr. Lilge chimed in during TLT's St. Michael move announcement, that he'd be helping them still going forward. I imagine GBM, and NSCLS will both need special dosimetry for any targeted PDT.
CancerSlayer wrote: Eoganacht wrote: It's hard to know exactly how this is going to progress. Systemic instillation followed by precision PDT with NIR light in conjunction with low level X-ray irradiation is one option that has been talked about. There is also the possibility they will use nanoparticles to down-convert some X-ray photons to visible light photons. Dr. McFarland has talked about this possibility. Whatever they end up doing they will not likely kill all of the cancer cells with the treatment, which is why it's so important that the procedure induces immunogenic cell death which is critical for antitumour immunity.
CancerSlayer wrote: Thanks Eoganacht....
Organometallic medicine/PDT is certainly proving its worth....and to think that a single compound (TLD-1433/Rutherrin) could potentially impact human disease in so many ways (cancer, viral/bacterial/fungal/parasitic diseases) is an absolute wonder. I think its real value will arise from its versatility.
Dr. Lilge's work re: personalized/precision PDT should also help towards defeating some of the more fastidious cancers. However, it's hard not to appreciate the simple elegance in TLD-1433's mechanism of action/versatility that enables it to broaden its kill zone irrespective of cancer or viral type. Furthermore, its potential to perform without the need for precision PDT (I.e. using lower-dose external radiation/x-ray, or possibly used independently in the case of viral disease) is what makes this investment even more exciting....JMHO. Good luck...
Well stated & yes...I imagine they may use all of the ACT armamentarium at their disposal to maximize a successful outcome....systemic Rutherrin with low-dose radiation/x-ray, followed by intra-operative/targeted PDT...with the hopes of stimulating a maximal immunogenic response. And yes, nano scintillation shows great promise & comes in various human-friendly forms....topic for another day. TLT has built quite the scientific team!