Ceapro Inc V.CZO

RE:RE:RE:A pill? What about a PGX-YBG immune boost?

[archeo753]

I doubt that Gilles would be investing up to $10 million in the German plant if he didn't already have a customer lined up for the PGX-YBG product.  Unfortunately it will be a while before we see any revenue from this unless there is another earlier way to market for PGX-YBG without the German plant up and running.

prophetoffacts wrote: As vaccines are no longer seen as a silver bullet CZO is preparing a PGX-YBG immune boost.
Gilles is a visionary.

prophetoffacts wrote:

Could the Induction of Trained Immunity by β-Glucan Serve as a Defense Against COVID-19?

Anne Geller1,2 and Jun Yan2*

• 1Department of Microbiology and Immunology, University of Louisville School of Medicine, Louisville, KY, United States
• 2Immuno-Oncology Program, Division of Immunotherapy, Department of Surgery, The James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, KY, United States

As the SARS-CoV-2 virus wreaks havoc on the populations, health care infrastructures and economies of nations around the world, finding ways to protect health care workers and bolster immune responses in the general population while we await an effective vaccine will be the difference between life and death for many people. Recent studies show that innate immune populations may possess a form of memory, termed Trained Immunity (TRIM), where innate immune cells undergo metabolic, mitochondrial, and epigenetic reprogramming following exposure to an initial stimulus that results in a memory phenotype of enhanced immune responses when exposed to a secondary, heterologous, stimulus. Throughout the literature, it has been shown that the induction of TRIM using such inducers as the BCG vaccine and β-glucan can provide protection through altered immune responses against a range of viral infections. Here we hypothesize a potential role for β-glucan in decreasing worldwide morbidity and mortality due to COVID-19, and posit several ideas as to how TRIM may actually shape the observed epidemiological phenomena related to COVID-19. We also evaluate the potential effects of β-glucan in relation to the immune dysregulation and cytokine storm observed in COVID-19. Ultimately, we hypothesize that the use of oral β-glucan in a prophylactic setting could be an effective way to boost immune responses and abrogate symptoms in COVID-19, though clinical trials are necessary to confirm the efficacy of this treatment and to further examine differential effects of β-glucan's from various sources.
...

While the excitement regarding the use of BCG as a prophylactic treatment for COVID-19 is warranted, considering that β-glucan can be administered orally, has an extremely high safety profile, does not require a person to access healthcare to receive the treatment, and is known to act similarly to the BCG vaccine in terms of augmenting innate immune responses, there is a strong argument to be made in favor of the use of β-glucan to prophylactically treat against COVID-19 as well. Here-in, we will highlight the known anti-viral impacts of β-glucan, review the known mechanisms of β-glucan-induced TRIM that could lead to protection against COVID-19, and present our personal view about the immune response to SARS-CoV-2 in the scope of TRIM. Additionally, though there is strong evidence to support the use of β-glucan as an anti-viral agent, COVID-19 has presented with a unique clinical course that involves the development of cytokine storm and thromboembolic events which often lead to mortality. As such, it is also important to consider that the immunostimulatory effects of β-glucan could be detrimental to the subset of patients who do develop cytokine storm and hyperinflammation, and so further research and understanding of the anti-viral mechanisms of β-glucan are needed before conclusions are made, which will also be discussed.
Frontiers | Could the Induction of Trained Immunity by β-Glucan Serve as a Defense Against COVID-19? | Immunology (frontiersin.org)