RE:Can someone enlight me with transaminase mistery...Edou111 wrote:
I would like you enlight me with this please. During PH2 adjudication yields transaminase rates lower at an acceptable level. Knowing that PH2 doses were higher than the AME trials, how could we logically explain such a failure at lower doses ? And remember that transaminase thing is what made the stock retreat after PH2 results even after adjudication. I am a bit confused to say the least...
I'm likely speaking out of my tush right now but ...
Using Dan's analogy of the liver marinating in Naproxen ... this may be beyond the normal effect as seen by Naproxen alone and more attributable to the Naproxen/H2S combo over longer periods of time.
For all we know, this marinating effect (accompanied by a possible protective effect from H2S) may affect people in very different ways.
As we age, we know the cell-to-cell H2S communications within the body usually become less efficient. What happens if your H2S cell-to-cell communication is still pretty healthy and we further drive excess H2S at you? Maybe something like that isn't easily measured by complicates what we see.
Who knows.
All I'm really saying is, there's likely a lot happening at the cell level that we can't explain effectively right now ... but ... maybe we'll get there.