New Patent + Advancing New DPEP-1 Drugs = Phase II Results TORONTO, June 10, 2021 (GLOBE NEWSWIRE) -- Arch Biopartners Inc. (“Arch” or the “Company”) (TSX Venture: ARCH and OTCQB: ACHFF), a clinical stage company developing new drug candidates for treating organ damage caused by inflammation, announced today it has filed a new provisional patent application with the U.S. Patent and Trademark Office to protect new antibody drug candidates that target inflammation in the lungs, liver and kidneys mediated by dipeptidase-1 (DPEP-1).
The new patent filing can potentially lead to novel single domain antibodies or monoclonal antibodies that inhibit DPEP-1 and organ inflammation. These new antibodies create a third class of drug under development at Arch focused on DPEP-1, alongside the current peptide candidates led by LSALT peptide (Metablok) and the small molecule, cilastatin.
Antibody drugs such as these typically display more specific receptor targeting and longer half-life in the bloodstream compared to peptides or small molecules. The development of DPEP-1 targeting antibody drugs provides the Arch platform with another class of therapeutics for diseases involving the lungs, kidneys and liver where inflammation plays a prominent role.
“This new class of antibodies that we are developing at Arch Biopartners strengthens our patent portfolio and broadens our drug platform targeting organ inflammation mediated by DPEP-1,” said Richard Muruve, CEO of Arch Biopartners.
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TORONTO, July 14, 2021 (GLOBE NEWSWIRE) -- Arch Biopartners Inc. (“Arch” or the “Company”) (TSX Venture: ARCH and OTCQB: ACHFF), a clinical stage company developing new drug candidates for treating organ damage caused by inflammation, announced today that Arch scientists have been awarded a Canadian Institutes of Health Research (CIHR) Team Grant worth $750,000 to study the potential benefit for the LSALT peptide (Metablok) to prevent inflammation in chronic kidney and lung diseases.
The CIHR grant entitled “Therapeutic Targeting a Shared Inflammation Pathway in the Lungs and Kidneys” was awarded to a research team at the University of Calgary led by Arch scientists Dr. Donna Senger and Dr. Daniel Muruve. The new grant will help further the understanding of the novel mechanism of action for organ inflammation first described in the journal Cell by Dr. Senger and her team in 2019. The grant was one of five awarded in the CIHR Team Grant competition “Preparation to Trial in Inflammation for Chronic Conditions”.
To date, the LSALT team has worked to establish dipeptidase-1 (DPEP-1) as an adhesion receptor for neutrophils (white blood cells) in the lungs, liver and kidneys. This neutrophil recruitment often causes acute inflammation and organ injury in patients during critical illness including acute kidney injury (AKI) and acute respiratory distress syndrome (ARDS).
The grant will be used to conduct pre-clinical studies to assess the potential of LSALT peptide as a treatment to prevent chronic kidney or lung disease, which are common long-term consequences in people who experience AKI or ARDS.
The grant will also be used to determine the optimal design of clinical trials targeting DPEP-1 to prevent chronic disease in critically ill patients. Finally, a portion of the funds will support ongoing pre-clinical studies to advance next generation drug candidates held within the Arch portfolio that target the DPEP-1 pathway.
IMHO