Theratechnologies Inc T.TH

Alternate Symbol(s): THTX

Healthcare Biotechnology

Theratechnologies Inc. is a Canada-based clinical-stage biopharmaceutical company. The Company is focused on the development and commercialization of therapies addressing unmet medical needs. It markets prescription products for people with human immunodeficiency viruses (HIV) in the United States. The Company's research pipeline focuses on specialized therapies addressing unmet medical needs in HIV, nonalcoholic steatohepatitis (NASH) and oncology. Its medicines include Trogarzo and EGRIFTA SV (tesamorelin for injection). Trogarzo (ibalizumab-uiyk) injection is a long-acting monoclonal antibody which binds to domain 2 of the CD4 T cell receptors. EGRIFTA SV (tesamorelin for injection) is approved in the United States for the reduction of excess abdominal fat in people with HIV who have lipodystrophy. Its portfolio includes Phase I clinical trial of sudocetaxel zendusortide (TH1902), a novel peptide-drug conjugate (PDC), in patients with advanced ovarian cancer.

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Theratechnologies Inc > Patient Protocol Questions

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Comment by SPCEO1on Nov 14, 2021 5:40pm

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Post# 34125244

RE:RE:Patient Protocol Questions

It wasn't easy!

First, while the presentation was running, I did a print screen when that slide was up. I then opened that in Microsoft Paint. I then copied it into Word. I then saved it as a picture. I then opened up IMGUR.com and browsed through my pictures to find it and loaded it up there. I then copiedd the link for the picture into Stockhouse. I then clicked on that link before I even posted the message. That opened the picture in another tab and I was able to copy it from there and paste it into a new post. And somehow, it showed up in the actual post.

I am sure there is an easier way!

Here is an ugly version of the earlier protocol slide inc ase anyone wants easy access to it:

Wino115 wrote: First, which technique allowed you to get the picture in here? I've never figured that out.

I"ll let the dosage experts opine on this, but I think Qwerty pointed out that past patients all get increased along with the new ones if they are still viable patients. He guessed there's maybe 3 that made it up to 300 and would be upped to 400 level if that one has no DLT. I'm still as confused as you are on this though.

SPCEO1 wrote: Sorry for the tests - just trying to sort out the copying an image issue using the technique wino suggested.

So, since the first patient died, let's assume the others have lived just for argument's sake. Since we know we have advanced to the 420 level, does that mean that only one patient has recieved drug at the 300 level or did all of the 4 assumed remaining patients advance to the 300 level? If only one patient got a dosage at the 300 level, is that good enough for the FDA? I would think they would want multiple patients to have shown no toxicity at that level before establishing it as the MTD.

Why did TH use the rpevious slides of this variety that were clearly not what was going on? And how could it take this long to dose just 6 patients overall? Should we be concerned about the seemingly very slow pace of the trial? I am continuously amazed at how drug companies always massively underestimate the time period for a trial to be completed.

Do they have to get to at least 15 patients for the trial to end?