Theralase Market potential $1.1 billion243,308 new cases of bladder cancer each year in the U.S., Canada and Europe(1)
70%-168,000 are classified as NMIBC(2)
30%-50,400 become unresponsive to current standard of care treatment Bacillus Calmette-Gurin ( “BCGUnresponsive”) within 1 year(3)
Patients that fail BCG treatment are prescribed a radical cystectomy (5) (surgical removal of bladder and associated tissue)
Estimated: 80,470 new cases in US, and 11,838 new cases in Canada, 151,000 new cases of bladder cancer in Europe in 2019(1)
240,000(1) x 70%(2) x 30%(3) x ½ x $50,000(6) =
$1.1 billion
Patients in need, urgent demand for bladder cancer drug
Willingness to pay $50K - $150K(6)
Bladder cancer patients facing low quality of life after cystectomy From diagnosis to death, it will cost bladder cancer patients $89K-$200K(7) , as bladder cancer is the most expensive cancer to treat.
1) Key Statistics for Bladder Cancer – American Cancer Society (2018); Canadian Cancer Society (2019) and Bladder Cancer – European Cancer Patient Coalition
(2) https://www.uptodate.com/contents/bladder-cancer-treatment-non-muscle-invasive-superficial-cancer-beyond-the-basics#!
(3) The management of BCG failure in non-muscle-invasive bladder cancer: an update (2009)
(4) European Organization for Research and Treatment of Cancer (EORTC) - (Veeratterapillay R, Heer R, Johnson MI, Persad R, Bach C. High-risk non-muscle-invasive bladder cancer-therapy options during intravesical BCG Shortage. Curr Urol Rep. 2016;17:68) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5769243/
(5) NCCN Guidelines Insights: Bladder Cancer, Version 5.2018, J Natl Compr Canc Netw 2018;16(9):1041–1053
(6) Willingness to pay per quality adjusted life year (QALY) for competitor drug, Pembrolizumab. Source: Cost-effectiveness of Pembrolizumab in Second-line Advanced Bladder Cancer, July 2018 (7) Sievert KD, Amend B, Nagele U, et al. Economic aspects of bladder cancer: what are the benefits and costs?. World J Urol. 2009;27(3):295–300. doi:10.1007/s00345-009-0395-z (8) 2025 estimated bladder cancer market (US, France, Germany, Italy, Spain, UK & Japan). Source: Global Data: Bladder cancer market size to more than triple to over $1.1 billion by 2025, April 2017