RE:RE:RE:RE:RE:RE:RE:RE:RE:RE:$tltff The FDA wants an option that has rates better thenThe updated protocol/bladder volume calculation (although not perfect) should help maximize the exposure/surface area of the inner bladder wall. However, "old" bladders tend to be less expansile & this will pose an ongoing challenge imo. I imagine over time there will be additional modifications made to help improve dosing, such as what enrique suggested (changing a patient's body position to possibly allow for more even drug distribution...this is done intraoperatively to maximize chemo treatment of certain intra-abdominal tumors that affect the inner lining of the abdomen or peritoneum). JMO.