RE:RE:Key to Alzheimer’s Lies in Gut Not Brain, Says New Study.. BURLINGAME, Calif., July 6, 2022 /PRNewswire/ -- Amid repeated failures of drug trials for Alzheimer's disease, a small pilot study using a precision medicine approach has reported the first promising results, improving cognitive scores in over 80% of patients, as published in the Journal of Alzheimer's Disease1. The team of physicians at three different sites achieved improvement in cognitive testing, brain training scores, partner-assessed symptoms, and even MRI measurements of regional brain volumes.
The patients ranged in age from 50 to 76 years and had either mild cognitive impairment (MCI) or early dementia, similar to the patients in recent pharmaceutical trials. However, when it came to treatment, the team took a fundamentally different approach from previous trials: instead of treating with a single drug that may have nothing to do with the underlying drivers of cognitive decline, the physicians sought the root cause contributors to decline by gathering more data — evaluating inflammation; deficiencies of nutrients, hormones and growth factors; gut and oral microbiomes; leaky gut; metabolic status; sleep apnea; genetic factors such as a tendency to blood clotting; vascular abnormalities; specific pathogens and toxins; and other potential contributory factors. The identified root causes, which were different from patient to patient, were then targeted with a personalized, precision medicine protocol for nine months, leading to unprecedented improvements, including some patients who increased their cognitive scores from the dementia range to normal.
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The key to stopping dementia could lie in the gut rather than the brain, new research suggests. Decades of studies from around the world costing billions of pounds have so far failed to uncover a way of tackling the memory-robbing disease. But the gut “represents an alternative target that may be easier to influence with drugs or diet changes”, experts have said.
A series of experiments linking the gut to the development of Alzheimer's were presented at the Alzheimer's Research UK 2022 Conference in Brighton on March 1...
https://english.aawsat.com/home/article/3511291/key-alzheimer%E2%80%99s-lies-gut-not-brain-says-new-study