Theratechnologies Inc T.TH

Alternate Symbol(s): THTX

Healthcare Biotechnology

Theratechnologies Inc. is a Canada-based clinical-stage biopharmaceutical company. The Company is focused on the development and commercialization of therapies addressing unmet medical needs. It markets prescription products for people with human immunodeficiency viruses (HIV) in the United States. The Company's research pipeline focuses on specialized therapies addressing unmet medical needs in HIV, nonalcoholic steatohepatitis (NASH) and oncology. Its medicines include Trogarzo and EGRIFTA SV (tesamorelin for injection). Trogarzo (ibalizumab-uiyk) injection is a long-acting monoclonal antibody which binds to domain 2 of the CD4 T cell receptors. EGRIFTA SV (tesamorelin for injection) is approved in the United States for the reduction of excess abdominal fat in people with HIV who have lipodystrophy. Its portfolio includes Phase I clinical trial of sudocetaxel zendusortide (TH1902), a novel peptide-drug conjugate (PDC), in patients with advanced ovarian cancer.

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Theratechnologies Inc > Recent study

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Comment by palinc2000on Oct 07, 2022 5:38pm

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Post# 35013329

RE:RE:RE:Recent study

You are hard to follow? You once posted that prostate cancer was not a valid target and critisize the company for incl a cancer type which in your opinion should not have been included and now you state the opposite...Why dont you ever tell the whole story and admit that you were dead wrong...?

jfm1330 wrote: Another reference confirms that sortilin is overexpressed and involved in neuroendocrine tumors and metastasis of these tumors. Good for me to read that, hope for the future. Imagine being saved at some point in time y the company I was invested in. It would be an amazing story.

The article also confirms overexpression of sortilin in aggressive prostate cancers, which is good for us to know considering the results of phase Ia. This article also confirms what I was talking about the other day, sortilin is found in the membranes of the Golgi apparatus and the endoplasmic reticulum, which could explain why through endosome internalization TH1902 can bypass efflux pump. Also, Golgi and ER are involved with tubulin, the protein that docetaxel is interacting with.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884004/

Wino115 wrote: Great find. Ours boys research is mentioned twice - footnotes 38 and 88. Getting some recognition for the PDC and sort1 target!

jeffm34 wrote: https://mdpi-res.com/d_attachment/ijms/ijms-23-11888/article_deploy/ijms-23-11888.pdf?version=1665063006