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Theratechnologies Inc T.TH

Alternate Symbol(s):  THTX

Theratechnologies Inc. is a Canada-based clinical-stage biopharmaceutical company. The Company is focused on the development and commercialization of therapies addressing unmet medical needs. It markets prescription products for people with human immunodeficiency viruses (HIV) in the United States. The Company's research pipeline focuses on specialized therapies addressing unmet medical needs in HIV, nonalcoholic steatohepatitis (NASH) and oncology. Its medicines include Trogarzo and EGRIFTA SV (tesamorelin for injection). Trogarzo (ibalizumab-uiyk) injection is a long-acting monoclonal antibody which binds to domain 2 of the CD4 T cell receptors. EGRIFTA SV (tesamorelin for injection) is approved in the United States for the reduction of excess abdominal fat in people with HIV who have lipodystrophy. Its portfolio includes Phase I clinical trial of sudocetaxel zendusortide (TH1902), a novel peptide-drug conjugate (PDC), in patients with advanced ovarian cancer.


TSX:TH - Post by User

Comment by scarlet1967on Oct 30, 2022 4:12pm
75 Views
Post# 35058695

RE:RE:RE:RE:RE:Principal investigator for TH1902

RE:RE:RE:RE:RE:Principal investigator for TH1902This is listed in inclusion criteria. The PH measurement can be done in vivo or ex vivo mostly by labeling the cells and imaging it.
"An adequate tumor sample must be available from core needle biopsies obtained during the Screening Period and following the subject's most recent systemic therapy."
 


qwerty22 wrote:

I don't see any pre-screening here. I don't think it's technically possible if the screen is for pH.

https://clinicaltrials.gov/ct2/show/NCT04902872?term=Cybrexa&draw=2&rank=1

The interesting thing they did was demand a post treatment biopsy that allows them to look for PDC and released payload in that tumour sample. Be interesting to know if THTX got any post-treatment samples.

 

qwerty22 wrote:

 

How do they pre-screen for acidity? Going to have to look that up.

 

scarlet1967 wrote:

 

 

My understanding is their peptide can enter acidic tumour cell surfaces which is common for proliferating cancer cells but the low PH level varies in different cancers.

As per their trial they pre screen patients(biopsies)!

So after all perhaps it wasn’t maybe only luck!

I do like the fact they did issue a PR pretty fast when they had the early results and I wish THTX if and when have reportable results release it pretty fast as well to/for us retail investors and not sitting on it for months.

 

 

 




 

qwerty22 wrote:

 

Just for comparison
May 2021 they announce first patient dosed (THTX MAR 2021)
Oct 2022 they are announcing 18 evaluable patients (THTX JULY 2022)

Pretty much similar timelines.

Big difference is they got one complete responder in their first 3 patients dosed so they were able to put out an early sign of efficacy PR in Oct 2021. Lucky dogs.

These guys are a private company so they don't have the same obligations to go public with data but they aren't revealing much about anything else. Vague statement on safety/tolerability. Nothing on other Ph1 stuff like pK, stability etc.

 

scarlet1967 wrote:

 

She is the principal investigator at MD Anderson also in charge of TH1902 trial.

This was her comments about another PDC at the Clininc:

 

“In this phase I study, CBX-12 demonstrated safety and tolerability, without significant gastrointestinal toxicity. We also saw signal of antitumor activity in multiple tumor types, said principal investigator, Funda Meric-Bernstam, M.D., Chair of the Department of Investigational Cancer Therapeutics at The University of Texas MD Anderson Cancer Center.”

 

https://www.globenewswire.com/news-release/2022/10/28/2543911/0/en/Cybrexa-Therapeutics-Presents-Findings-from-First-in-Human-Study-of-CBX-12-as-a-Plenary-Oral-Presentation-at-34th-EORTC-NCI-AACR-Symposium.html

 

Looking at her profile she seems to be the right choice for TH1902 so hopefully we get a similar PR with encouraging comments from her about TH1902.

 

 

 

 

 

“Funda Meric-Bernstam is the Chair of the Department of Investigational Cancer Therapeutics -- the Phase I Program, and the Medical Director of the Institute for Personalized Cancer Therapy at MD Anderson Cancer Center. She has a basic and translational research program that is focused on molecular therapeutics, to delineate the mechanism of action of each agent targeting this pathway and the molecular alterations useful to prospectively identify patients who will benefit most from each agent, and optimal combination therapies with targeted therapies and novel immune-modulators. She is an active clinical trialist focused on Phase I trials, and rationale combinations, biomarker-driven therapy and immune-oncology.”

 

Funda Meric-Bernstam | MD Anderson Cancer Center


 


My understanding is their peptide can enter acidic tumour cell surfaces which is common for proliferating cancer cells but the low PH level varies in different cancers.

As per their trial they pre screen patients(biopsies)!

So after all perhaps it wasn’t maybe only luck!

I do like the fact they did issue a PR pretty fast when they had the early results and I wish THTX if and when have reportable results release it pretty fast as well to/for us retail investors and not sitting on it for months.

 

 

 


 




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