RE:RE:RE:RE:RE:RE:TH-1902 pause is no reason to blame managementThe problem with chemo drugs like docetaxel, doxorubicin or SN38, is that you need selective cleavage of the linker inside the cells. That means part of it will cleave outside the cells, in the bloodstream. One of the big advantage of radioisotopes, is that cleavage from linker is not needed, in fact, it needs to be completely avoided. All you need is PDC bonding with the receptor and internalization. If TH19P01 can do that, this part of the concept works. The other part of the concept would be related to sortilin expression throughout the human body and tumors. What is the distribution of sortilin within the human body and how much of the PDC is it catching? This is key for toxicity and Ga68 would allow to measure that. Ga68 could also allow to select only the right patient that are overexpressing enough sortilin on the cancer cells.
LouisW wrote: Maybe SN38 is doable? I guess they already have some data. jfm1330 wrote:
TH1902 TH19P01 PDC Aeterna Zentaris PDCAEZS-108 Zoptrex PDC Thera Ib TH1902 TH19P01 “” PDC PDC ADC Lutathera PluvictoLu177-Dotatate Lu177-PSMA Lu177 DOTA Pluvicto “”Thera TH19P01 DOTA TH19P01 Lu177 Ga68 Ga68 “” Ga68 Lu177 I Ga68 Lu177 Lu177 TH19P01 DOTA-Lu177 DOTA-Ga68 ADC