RE:What if its not the plaques and tangles. What info RC? You're such a tease.
Cashman has been fighting the plaque hypothesis since day 1 (I don't know about tangles) so this plus his alternative misfolding (as both trigger and opportunity) hypothesis is what drew me in.
ACH as many media critics still describe it is decades out of date, so at this point its only still out there for spin purposes. IMO ABO also has some built-in spin, as I've commented re Acumen, but it's still a logical step in what we shareholders all hope will be the right direction.
Misfolding, as the key event in what is still a cascade, seems a brilliantly logical place to look for a solution, brilliant but long waiting for the right combination of technologies, talent, and tangential field results (prion diseases).