RE:RE:RE:RE:RE:RE:SPEach study that was listed was using pelareorep as a monotherapy.
What was discovered was that neither pelareorep or PD-(L)1 immune checkpoint inhibitors work well as a single agent monotherapy.
What also was discovered was that pelareorep + PD-(L)1 immune checkpoint inhibitors when combined were synergistic and that the 2 agents together worked better than either alone.
How many times does tthat need to be posted before you begin to understand?
What also has been discovered is thst pelareorep and immune checkpoint inhibitors work in certain cancers better than others. How many times does that need to be posted?
And what has been discovered is that the immune system is primed by pelareorep when pelareorep is administered in advance of a PD-(L)1 immune checkpoint inhibitor. This was discovered through the various clinical trials with pelareorep that are listed.
And what has been further discovered is that pelareorep can remodel the tumor microenvironment (TME) from hypoxic to one conducive to checkpoint inhibition. Once again found through the process of scientific discovery.
Also recently discovered through the clinical trial process was that the I/O combination of pelareorep + PD-L1 immune checkpoint inhibitors was effective in pancreatic cancer - with early results showing a complete response and stable disease responses.
And what pelareorep's scientific journey of discovery has brought us to is the point where 2 Phase 3 studies could bring 2 accelerated approvals with them.
And how many more times does this have to be posted?