RE:RE:Merck to buy Prometheus Bio....Venture009,
With respect, you stringing together disappointments and lumping things together that do not make sense.
The sample sizes of all our trials are driven by cost and the difficulty of getting participants, as well as the purpose of the trials at that stage. The sample sizes were set large enough to accomplish the purposes of the trials, and approved by regulators. Even with large sample sizes we are still doing sampling and statistical tests, which themselves have developed as a sort of a standard but still do not bring certainty about success in treating cancer. Nothing is a sure thing. However adverse side effects (even perhaps death) from all stanard chemo and rad treatments ARE a sure thing. We have no adverse side effects worth mentioning.
The H and N trial was run in strange ways (Brad was in charge), involved tossing out lots of subjects who had fevers, and ultimately ONCY was told by the FDA to split the samples, learn from the experience and come back in the future.
This BS about there being some fatal flaw in pela is just that, BS. There is no evidence. to that effect. The results of last fall and the last few years working with i/o combos belies the idea that there is some hidden reason that big pharma does not want us. Uber on Yahoo says that Pfizer passed on ONCY 20 years ago, so why would they want us now? The answer is: I/O emergence and our results.