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Oncolytics Biotech Inc T.ONC

Alternate Symbol(s):  ONCY

Oncolytics Biotech Inc. is a clinical-stage biotechnology company. The Company is focused on developing pelareorep, an intravenously delivered immunotherapeutic agent that activates the innate and adaptive immune systems and weakens tumor defense mechanisms. This compound induces anti-cancer immune responses and promotes an inflamed tumor phenotype turning cold tumors hot through innate and adaptive immune responses to treat a variety of cancers. This improves the ability of the immune system to fight cancer, making tumors more susceptible to a broad range of oncology treatments. The Company’s primary focus is to advance its programs in hormone receptor-positive / human epidermal growth factor 2- negative (HR+/HER2-) metastatic breast cancer and advanced/metastatic pancreatic ductal adenocarcinoma to registration-enabling clinical studies. In addition, it is exploring opportunities for registrational programs in other gastrointestinal cancers through its GOBLET platform study.


TSX:ONC - Post by User

Comment by westcoast1000on Apr 30, 2023 2:11pm
176 Views
Post# 35421715

RE:RE:RE:RE:RE:RE:RE:RE:ASCO relevance

RE:RE:RE:RE:RE:RE:RE:RE:ASCO relevanceThanks, Eileen. I do not have knowledge of what a P3 is worth on average, but it should be driven in part by the size of the prize at the end if the p3 works, and the likelihood it works.

From what I can gather, the size of the prize for both mBC and Panc are very huge. the likelihood is works has got to very high, IMHO, for this reasons.

Let us consider panc. To my knowledge, after looking through Pfizer reports, Tecentriq and the chemo combo that they use for a variety of indications is already approved. In fact, Tecentriq sales account for 15% of their total pharma revenues.

If we add pela to that combo, my lay understanding is that is would enhance the number of people who will get benefit, becuase of the effects on the TMI. In addition, the biomarkers should help eliminate possible patients whose immune system is already too far gone to be helped much. So in that way, given the tecentriq combo is already approved, should it not be a slam dunk to pass the efficicacy aspect of FDA trials. And we already know pela is safe on its own, and Tecengtiq is safe enough to be in use.

So should the panc P 3 be a near slam dunk? Combine that with a huge potential market, and I cannot see the hold-up other than waiting for data and bidders.

I hope that people will correct any misjudgements I have outlined above. Thanks for the greater strength of participation on this board. 
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