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Oncolytics Biotech Inc ONCY


Primary Symbol: T.ONC

Healthcare Biotechnology
Oncolytics Biotech Inc. is a clinical-stage biotechnology company. The Company is focused on developing pelareorep, an intravenously delivered immunotherapeutic agent that activates the innate and adaptive immune systems and weakens tumor defense mechanisms. This compound induces anti-cancer immune responses and promotes an inflamed tumor phenotype turning cold tumors hot through innate and adaptive immune responses to treat a variety of cancers. This improves the ability of the immune system to fight cancer, making tumors more susceptible to a broad range of oncology treatments. The Company’s primary focus is to advance its programs in hormone receptor-positive / human epidermal growth factor 2- negative (HR+/HER2-) metastatic breast cancer and advanced/metastatic pancreatic ductal adenocarcinoma to registration-enabling clinical studies. In addition, it is exploring opportunities for registrational programs in other gastrointestinal cancers through its GOBLET platform study.


TSX:ONC - Post by User

Oncolytics Biotech Inc > ONCY Presented Positive GOBLET Pancreatic Cancer Data @ ESMO
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Comment by Noteableon Dec 03, 2023 9:54pm
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Post# 35766385

RE:ONCY Presented Positive GOBLET Pancreatic Cancer Data @ ESMO

RE:ONCY Presented Positive GOBLET Pancreatic Cancer Data @ ESMOONCY has identified changes in blood T cell populations as a potential biomarker to predict patient response.

And as already posted:

Overall (TCR) TILS is a strong prognostic biomarker in an early stage setting. ONCYs GOBLET study further confirmed T cell diversity and TCR clonality as markers of ICIs efficacy in combination with pelareorep.

ONCYs TCR (TiLs) biomarker data as been further validated,as outlined in ONCYs press release:

https://www.sciencedirect.com/science/article/pii/S0923753421021852

T-Cell Populations: Analysis of changes of T-cell clones and tumor-infiltrating lymphocytes (TILs) showed:
  • Expansion of pre-existing and new T cell clones, including the expansion of TIL-specific clones
  • A correlation between the expansion in the blood of TIL-specific clones and tumor response
https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-teclistamab-cqyv-relapsed-or-refractory-multiple-myeloma

https://stockhouse.com/companies/bullboard?symbol=t.onc&threadid=35680394

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