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Oncolytics Biotech Inc T.ONC

Alternate Symbol(s):  ONCY

Healthcare Biotechnology
Oncolytics Biotech Inc. is a clinical-stage biotechnology company. The Company is focused on developing pelareorep, an intravenously delivered immunotherapeutic agent that activates the innate and adaptive immune systems and weakens tumor defense mechanisms. This compound induces anti-cancer immune responses and promotes an inflamed tumor phenotype turning cold tumors hot through innate and adaptive immune responses to treat a variety of cancers. This improves the ability of the immune system to fight cancer, making tumors more susceptible to a broad range of oncology treatments. The Company’s primary focus is to advance its programs in hormone receptor-positive / human epidermal growth factor 2- negative (HR+/HER2-) metastatic breast cancer and advanced/metastatic pancreatic ductal adenocarcinoma to registration-enabling clinical studies. In addition, it is exploring opportunities for registrational programs in other gastrointestinal cancers through its GOBLET platform study.


TSX:ONC - Post by User

Oncolytics Biotech Inc > ONCY pelareorep + CD3 bispecific antibody true-killer combo
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Comment by Noteableon Jan 31, 2024 12:14pm
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Post# 35855085

RE:RE:RE:RE:RE:RE:ONCY pelareorep + CD3 bispecific antibody true-killer combo

RE:RE:RE:RE:RE:RE:ONCY pelareorep + CD3 bispecific antibody true-killer comboJanuary 31, 2024 - Pfizer drops  PF-07260437, a phase 1 therapy designed to treat advanced breast cancer, ovarian cancer or endometrial cancer.

The B7-H4 x CD3 bispecific monoclonal antibody was intended to potentially help B7-H4 in favorably manipulating breast tumor immune microenvironment (TME), but was unable to achieve, and in which ONCY's pelareorep x CD3 has been able to unequivocally demonstrate by  inducing a local interferon response and strong T-cell influx, thereby sensitizing and remodeling the tumor microenvironment for the addition of a subsequent immune checkpoint inhibitor.

https://clinicaltrials.gov/study/NCT05067972?term=PF-07260437&rank=1


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