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Apogee Therapeutics Inc APGE

Apogee Therapeutics, Inc. is a clinical-stage biotechnology company. The Company is advancing novel biologics with the potential for differentiated efficacy and dosing in the inflammatory and immunology (I&I) markets, including for the treatment of atopic dermatitis (AD), asthma, eosinophilic esophagitis (EoE), chronic obstructive pulmonary disease (COPD), and other I&I indications. APG777, the Company’s most advanced program, is being initially developed for the treatment of AD. With four validated targets in its portfolio, it is seeking to achieve efficacy and dosing through monotherapies and combinations of its novel antibodies. Its most advanced programs are APG777, APG990, APG333, and APG808. APG990 is an SQ extended half-life mAb that utilizes advanced antibody engineering to target OX40L. APG333 is a fully human mAb against thymic stromal lymphopoietin (TSLP). APG808 is an SQ extended half-life mAb targeting IL-4Ra. APG279 is for the dual inhibition of OX40L and IL-13.


NDAQ:APGE - Post by User

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  • MikeTesterX
Post by MikeTesteron Jan 24, 2025 2:59am
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Post# 36418409

Reshaping the Standard of Care in Inflammatory and Immunolog

Reshaping the Standard of Care in Inflammatory and ImmunologLooks like APGE is making some serious moves in the inflammatory disease space. Their APG777 with a 75-day half-life is pretty impressive compared to current AD treatments. Phase 2 trial coming in H2 2025 could be a big catalyst. $754M cash runway into Q1 2028 gives them plenty of runway to develop their pipeline.Watching closely on the combo therapy plans with APG777 and APG990 - targeting multiple inflammatory pathways could be a game changer. No debt and strong cash position makes this an interesting biotech play. Might start a small position and add if Phase 2 data looks promising.BTW, BeyondSPX continues to deliver high quality in-depth analysis on just about every US stock out there, even microcaps, for free. Great resource for digging into emerging biotech stories like this one.                         https://beyondspx.com/article/reshaping-the-standard-of-care-in-inflammatory-and-immunology-diseases-a-closer-look-at-apogee-therapeutics-apge





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