Theratechnologies Inc T.TH

Moving on

[scarlet1967]

Ovarian cancer: Setback as major screening trial fails to save lives

Ovarian cancer: Setback as major screening trial fails to save lives

TH1904 seems to be targeting ovarian cancer as per google,:

“The global ovarian cancer therapeutic market reached $2.1 billion in 2017. The market should reach $2.9 billion by 2022, growing at a compound annual growth rate (CAGR) of 7.1% during 2017-2022.”

[juniper88]

The difference between TH1902 and TH1904 is the payload, nothing else.  Yes, Thera initially used TH1904 (doxorubicin payload) to for the preclinical ovarian cancer work.  But then they used TH1902 (docetaxol payload) and found it actually worked better on ovarian cancer. than TH1904. Sortilin receptor seems to be higher expressed as the disease gets to a later stage and the higher the

[realitycheck4u]

This post has been removed in accordance with Community Policy

[scarlet1967]

Sorry to hear about your wife's struggles but I am glad she responded well to the treatment. I think OHIP should cover the cost of a life saving treatment, it's absolutely disgraceful! I am not sure about whether TH1902 could be used as a maintenance treatment indefinitely but I came across another study which indicated the PDC technology can potentially treat metastatic TNB cancer so

[scarlet1967]

https://www.mdpi.com/1422-0067/22/9/4673

[scarlet1967]

I posted this earlier the article goes on also suggesting combination therapies as another approach to bypass the MDR. This article published yesterday emphasized the urgent need for a targeted drug therapy such as PDC for among others metastatic breast cancer due to multidrug resistance, Thus far a combination of anticancer drugs has been used as standard chemotherapy treatment although this

[qwerty22]

To add to what you say. You could imagine that if sortilin is a major mechanism for aggressiveness and plasticity in cancer cells then th1902 might be perfectly suited for clearing up those pesky cells that escape tumours and cause re-occurrence as in your wife's case, as you say it could be well suited to maintainance with a nice tolerability profile. The possibilities are endless (which

[Wino115]

Thank you for the insights.  Most of all, I hope the treatment works.  Any thoughts of trialing the TH1902 if it shows decent results?