Post by
jfm1330 on Jul 18, 2022 5:38pm
Complexity of sortilin
If you want to freak out about how complex the sortilin role can be, and how it can change from cell types, and even within the same cell type, read this very recent article published this year. Sortiln has over 50 possible ligands, and depending on the ligand, then the pathway within the cell can vary. Reading this article, it seems pretty clear that all sortilin expression is not the same and does not behave in the same way. In the context of TH1902, the big question that comes to mind is how sortilin in cancer cells compare to sortilin in healthy cells, and as I said, in healthy cells, the behavior of sortilin, so can it also vary from in cancer cells from on cancer type to another, and even within a cancer type depending on how advanced the cancer is. For example, is it the same in metastatic cancer as in non metastatic cancer? This article does not talk about cancer, it is focused on sortilin role in metabolism, but it is interesting to have an understanding of how complex the role of this receptor is. In the context of the recent press release about the grant to better understand the fate of TH1902 in TNBC, you can see that it will be a big task just to understand some aspect of it.
https://www.sciencedirect.com/science/article/pii/S0022227522000761