Theratechnologies Inc T.TH

Sortilin and Eyesight - side effect vs efficacy

[JayjayUSA12007]

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3338683/

This study is evidence that Sortilin is associated with the eyes.
Since TH902 is designed to attach to Sortilin, it causes the side effect to the eyes.
On the other hand, this so-called side effect indirectly shows that TH902 works as expected on human, since most cancer cells have Sortilin expressed on its surface.

As such, this is the question of Risk vs Benefits. The new trial protocol amendment is to strike a balance between them.

Furthermore, as TH902 is designed as salvage therapy, its benefits would likely weight more than potential risks, given these patients' conditions.

[qwerty22]

"Efficacy results observed thus far were not convincing enough to pursue enrolling patients and did not outweigh the adverse events seen in some patients." Reads like the obituary for the drug. What in that sentence is there to be hopeful about? Unconvincing efficacy and adverse events large enough to induce a voluntary halt. Obviously we'd need to know more but at this stage I