Theralase Technologies Inc. V.TLT

Newsletter out

[Oilminerdeluxe]

18 treated

[Oilminerdeluxe]

If i read it correctly, the 6 treated with the right dosage: Although very early for a statistical analysis the primary objective at 90 days for patients receiving the optimized primary Study Treatment demonstrates a 33.3% CR rate, with 50.0% data pending and only 16.7% with no response.

[fredgoodwinson]

Also concentrating on those 6 Oilminer and it is impossible for the 3 pending who dilute the % of success through their (bizarre IMHO) inclusion to register any positive outcome. At present they are very likely skewing the impression to an overly-negative one.   The Trial needs to run a while yet before meaningful conclusions can be drawn.   Here and have been for the last 7

[floatinketucky]

We cannot loose sight that 50 percent of optimized patients are pending data.  In total 6 patients were treated using the Study II treatment optimizations. A preliminary analysis of the primary objective at 90 days for patients receiving the optimized primary Study Treatment demonstrates a 33.3% CR rate, with 50.0% data pending and only 16.7% with no response.

[enriquesuave]

Yes that's the important part.  Patients 13-18 or the last 6 patients have all been treated with optimized procedure.  Of 13,14,& 15  2 are CR  or 2 out of 3 after single treatment or 67%.  Still waiting on 90 days for 16,17 & 18.  We need to significantly beat the competition which is 17-24% CR efficacy at 12 months to become next Gold Standard as we

[99942Apophis]

In total 6 patients were treated using the Study II treatment optimizations. A preliminary analysis of the primary objective at 90 days for patients receiving the optimized primary Study Treatment demonstrates a 33.3% CR rate, with 50.0% data pending and only 16.7% with no response. Bladder volume calculation Study drug volume calculation Study device volume calculation Study device

[99942Apophis]

sorry that didn't copy very well

[2b7f6fab]

I would also add the 2 of 3 complete response from Ph1b.   Those patients received the full dose and correct bladder/light calculations.  So that give us 4/6 showing complete response with 3 pending.  67% complete response and patient 4 from Ph1b shouldn't even be considered in the %.  Hence 4/5 or 80% CR with 3 pending.  Very possible we're looking at 7/8 CR

[enriquesuave]

By including the 1st 12 undertreated patients, the numbers look less attractive, but only once we can have data on 15-20 patients who correctly  treated with optimized procedure, then we will have a clear picture.  So far we can say 8 patients ( 2 from PH1 and 6 from PH2) have received an optimized treatment.  4 out of 5 valuable patients are CR and 3 pending.  That is 80% CR

[enriquesuave]

  Furthermore, 2nd treatment at 6 months mark can increase CR even further or at least maintain it.  IMO 

[Oilminerdeluxe]

The next newsletter could show us how the 3 pending patients are doing. If all of them are healthy, I suspect we will sing praises :-) Three more months, then we will mostlikely know a bit more.

[99942Apophis]

Yes enriquesuave  in my opinion there is a strong probability of 80% CR on the new optimized patients.  I agree with the future patient enrollment continued high CR numbers will of course improve the overall results and am very happy with this quarterly update. 

[DJDawg]

Perhaps obvious question - does the 90 day clock start ticking after two treatments at the optimized protocol or just one. My understanding is that the new protocol is a treatment at 0 and 6m. So the 50% of the 6 that are pending are they pending after having gotten two treatments or did some just get one.

[CancerSlayer]

    This is after 90 days.  The response of 3 patients have yet to be determined.  There have been only a total of 8 optimized patients (including two from Ph 1).  Of the 5 patients who have already been evaluated (3 are pending or yet to be determined), 4 have achieved a CR & the 1 non-responder shown above (i.e. unchanged CIS disease) will still get a