Theralase Technologies Inc. V.TLT

Tertiary objectives.

[tamarindo1]

Heck, most old guys experience many of these kinds of adverse effects on a daily basis.


In support of the tertiary objective, all patients have experienced some transient grade 1 or grade 2 AEs (e.g.: bladder spasms, constipation, urge incontinence, fatigue, urinary frequency, hematuria, penile discomfort, urinary urgency, pain, urinary tract infections and other) where > 80% have completely resolved with 180 days. One patient was diagnosed with urosepsis (infection in the urinary tract) that co

[enriquesuave]

Uro sepsis is one of the side effects of simply doing a cystoscope exam.  

[enriquesuave]

I wonder when will the partial responders be ruled out as either CR or not.  So far even at 6 months they are showing a negative cystoscope ( no visible cancer) but a positive urine cytology.  They have to use a uretoscope to examen for possible UTUC.   This is a very good sign that they are still showing no cancer with cystoscope after 6 months.  Numbers can go up dramatically

[enriquesuave]

It seems possible that either 13 or 14 or 15 was the patient who died as this patient showed negative urine cytology eliminating sign of cancer at 30 days, but unfortunately did not live long enough to get to 3 months exam. Just guessing here, as we only now learned of this outcome. If this was the case it would have been 3 on 3.  Just a guess.

[stocksnbonds458]

Enrigue your well thought out and technically accurate posts are much appreciated by all I am sure! I just wish it wasn't necessary for you to do this, to clear up the ambiguity and confusion introduced by Theralase's press releases. Maybe patients #5 and # 6 from phase 1 should be writing these Quarterly newsletters for now on, perhaps as a testament to almost 2 years cancer free.

[enriquesuave]

What I wrote earlier seems to make sense. Patients 13 and on got an Optimized Treatment.  There are 3 more patients pending for 90 days data (ie. patients 16, 17,18). Hence of 13,14 and 15 ,  2 are CR and unfortunately 1 died unrelated to treatment.  They do indicate in Quarterly that the patient who died had negative Urine cytology at 30 days ( hence no sign of cancer)and would

[tdon1229]

  Enrique, i wouldn't be too quick to dismiss the death as unrelated.  True, I think it's plain to see it's not from exposure to either the TLD-1433 or to the light source or the activation.  However, filling the bladder and holding it for an hour during instillation, with successive prerinses and post rinses, results in back pressure on the kidneys.  That can

[fredgoodwinson]

At first glance I couldn`t understand why the optimised treatment had apparently elicited no response whatsoever in one of the patients. TBH with my faith in the tech it came as a real shock.   Of course this is the patient who sadly died. Since there was no cancer in his/her urine at 30 days` I believe that had he/she lived we might still be on track for 100% CRs with the 6 most

[enriquesuave]

Now we can say that any and all treatments which require drug instillations can cause the same issue and is actually seen as a side effect of all of the other competition. 

[Pandora]

And there is a "good" point. This is one of the only drugs presenting side effects that does not include diarreah! ----  although it is the other channel. :-)) That's gotta be a plus for the old guys regardless. Infections = c-diff.