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Resverlogix Names Michael Sweeney, M.D., as Senior Vice President of Clinical Development

T.RVX, BIOGY

CALGARY, Nov. 3, 2014  /CNW/ -  Resverlogix Corp. (TSX:RVX) today announced the appointment of Michael T. Sweeney, M.D., as senior vice president of clinical development.

Dr. Sweeney, a cardiologist with extensive experience in pharmaceutical product development and marketing, will oversee clinical development programs for RVX-208 in cardiovascular disease (CVD), diabetes mellitus, and other indications. This will include the company's Phase 2/3 trial of RVX-208 in patients with high-risk CVD with low HDL and diabetes mellitus.

"As we continue the development of RVX-208 for chronic diseases like CVD and diabetes mellitus, Michael brings highly relevant clinical development experience to our company," said Donald McCaffrey, president and chief executive officer of Resverlogix. "His expertise in vascular and cardiology product development will be beneficial as we prepare for the initiation of the Phase 2/3 trial of RVX-208 in patients with CVD and diabetes mellitus. We are set to begin enrolling patients in the first half of 2015 and plan additional trials to evaluate the drug in other conditions like Alzheimer's disease, peripheral artery disease, and chronic kidney disease."

Dr. Sweeney has an impressive career history, including 11 years at Pfizer Inc., holding a variety of senior-level medical and marketing positions, including Senior Director, Urology Global Medical Group Leader and Director of marketing of the Viagra® Worldwide Team. Prior to joining Resverlogix, Dr. Sweeney was a strategic pharmaceutical consultant for Impax Pharmaceuticals, Inc., a specialty pharmaceutical company with drug delivery and formulation technology, where he prepared a European marketing authorization application (MAA) for a product to treat neurologic disease. Prior to Impax, Dr. Sweeney was Chief Medical Officer and vice president of research and development at Depomed, Inc., where he implemented the company's strategic plan for product development activities including opportunity assessment, clinical trials and interactions with the FDA. Prior to Depomed, Dr. Sweeney was vice president of medical affairs at CV Therapeutics, Inc., where he built the medical affairs department to enable the successful launch of Ranexa® for patients with cardiovascular disease and chronic angina. Dr. Sweeney also spent time as a senior clinical pharmacologist and a medical advisor at Zeneca Group PLC (prior to the AstraZeneca merger).

Dr. Sweeney holds biochemistry and medical degrees from Liverpool University and an advanced medical research degree from Manchester University in the U.K. Dr. Sweeney also holds post-graduate diplomas in pharmaceutical medicine and pharmaco-epidemiology from the University of London. He also is a fellow of the Royal College of Physicians of Edinburgh.

About RVX-208

RVX-208 is a first-in-class, small molecule selective BET bromodomain inhibitor. BET-Bromodomain inhibition is an epigenetic mechanism that can turn disease-causing genes either on or off, returning them to a healthier state. RVX-208 is the first and only BET inhibitor selective for BRD4-BD2, producing a nexus of biological effects with important benefits for patients with disease such as cardiovascular disease, diabetes mellitus, Alzheimer's disease, peripheral artery disease, and chronic kidney disease while maintaining an excellent safety profile. Resverlogix is planning to study RVX-208 in a Phase 2/3 clinical trial in CVD patients with diabetes mellitus and low HDL.

About Resverlogix

Resverlogix Corp. is developing RVX-208, a first-in-class, small molecule selective BET bromodomain inhibitor for the treatment of patients with cardiovascular disease, diabetes mellitus, Alzheimer's disease, peripheral artery disease, and chronic kidney disease. RVX-208 is the only selective BET bromodomain inhibitor in clinical trials. Resverlogix's common shares trade on the Toronto Stock Exchange (TSX: RVX). For further information please visit www.resverlogix.com. We can be followed on our blog at http://www.resverlogix.com/blog.

This news release may contain certain forward-looking information as defined under applicable Canadian securities legislation, that are not based on historical fact, including without limitation statements containing the words "believes", "anticipates", "plans", "intends", "will", "should", "expects", "continue", "estimate", "forecasts" and other similar expressions. In particular, this news release includes forward looking information relating to research and development activities and the potential role of RVX-208 in the treatment of cardiovascular disease, Alzheimer's disease, peripheral artery disease and chronic kidney disease. Our actual results, events or developments could be materially different from those expressed or implied by these forward-looking statements. We can give no assurance that any of the events or expectations will occur or be realized. By their nature, forward-looking statements are subject to numerous assumptions and risk factors including those discussed in our Annual Information Form and most recent MD&A which are incorporated herein by reference and are available through SEDAR at www.sedar.com. The forward-looking statements contained in this news release are expressly qualified by this cautionary statement and are made as of the date hereof. The Company disclaims any intention and has no obligation or responsibility, except as required by law, to update or revise any forward-looking statements, whether as a result of new information, future events or otherwise.

For further information, please contact:

Company Contacts:                                                           

Donald J. McCaffrey
President and CEO 
Resverlogix Corp.
Phone: 403-254-9252
Email: don@resverlogix.com

Sarah Zapotichny
Director, Investor Relations & Corporate Communications  
Resverlogix Corp.
Phone: 403-254-9252
Email: sarah@resverlogix.com

Media:

Tony Russo, Ph.D.
Matt Middleman, M.D.
Russo Partners, LLC
Phone: 212 845 4251
Phone: 212-845-4272
Email: tony.russo@russopartnersllc.com
Email: matt.middleman@russopartnersllc.com

SOURCE Resverlogix Corp.

Copyright CNW Group 2014