WARREN, N.J., June 16, 2016 (GLOBE NEWSWIRE) -- Bellerophon Therapeutics, Inc. (Nasdaq:BLPH), a clinical-stage
biotherapeutics company, announced today that the first subject has been enrolled in the Phase 3 INOvation-1 clinical trial.
The first patient was enrolled by Jeremy Feldman, MD, Principal Investigator at Arizona Pulmonary Associates, Ltd.
INOvation-1 is a clinical trial evaluating the efficacy and safety of the INOpulse® delivery system for the treatment of
patients with Pulmonary Arterial Hypertension (PAH) with an anticipated enrollment of 188 subjects in 17 countries. The
INOpulse delivery system utilizes a proprietary technology to deliver pulsatile inhaled nitric oxide allowing for use in a portable
chronic setting.
Bellerophon has also enrolled the first subject in a Phase 2 trial evaluating the safety and efficacy of the INOpulse delivery
system in patients with pulmonary hypertension associated with Idiopathic Pulmonary Fibrosis (PH-IPF) in collaboration with
Professor W. DeBacker, MD, Director Department of Pulmonary Medicine, University Hospital and University of Antwerp.
Jonathan Peacock, Chairman and Chief Executive Officer of Bellerophon Therapeutics, stated, “The initiation of enrollment in
INOvation-1, Bellerophon’s first Phase 3 trial in PAH, marks an important milestone for the company and offers a new potential
treatment to patients who continue to suffer poor outcomes. Additionally, with the initiation of the clinical trial in
IPF and a planned clinical trial in pulmonary hypertension associated with COPD, we are positioned to gain additional insight in
2016 for our future development programs for INOpulse.”
INOpulse Clinical Program Focus
The focus of the company’s INOpulse clinical program is the continued development of its nitric oxide therapy for patients with
pulmonary hypertension (PH). The lead indication for INOpulse is Pulmonary Arterial Hypertension (PAH), for which FDA issued
Special Protocol Assessment for the Phase 3 program and agreement was reached with European Medicines Agency (EMA) through its
Scientific Advice Working Party (SAWP) process. The Phase 3 program will include 2 confirmatory trials in approximately 450
patients. The primary endpoint for each trial is Six Minute Walk Distance (6MWD), with Time to Clinical Worsening (TTCW) as a
secondary endpoint, pooled across both trials. In February 2016, Bellerophon released encouraging results from the long-term
extension of the company’s Phase 2 PAH clinical trial demonstrating benefit for patients on long-term oxygen therapy whose disease
is progressing despite taking one or more existing PAH therapies. Bellerophon also plans to continue with Phase 2 testing in
PH associated with Chronic Obstructive Pulmonary Disease (PH-COPD) and PH associated with Idiopathic Pulmonary Fibrosis (PH-IPF)
for which results are anticipated by the end of 2016.
About Bellerophon
Bellerophon Therapeutics is a clinical-stage biotherapeutics company focused on developing innovative therapies at the
intersection of drugs and devices that address significant unmet medical needs in the treatment of cardiopulmonary diseases. The
Company is currently developing three product candidates under its INOpulse platform, a proprietary pulsatile nitric oxide delivery
system. The first is for the treatment of pulmonary arterial hypertension (PAH), for which the Company intends to commence Phase 3
clinical trials in 2016. The second is for the treatment of pulmonary hypertension associated with chronic obstructive pulmonary
disease (PH-COPD), which is in Phase 2 development and the third candidate is for the treatment of pulmonary hypertension
associated with Idiopathic Pulmonary Fibrosis (PH-IPF). The Company’s plans also call for the completion of further work on the use
of INOpulse to treat PH-COPD and PH-IPF during 2016. For more information, please visit www.bellerophon.com.
Forward-looking Statements
Any statements in this press release about our future expectations, plans and prospects, including statements about clinical
development of our product candidates and expectations regarding the sufficiency of our cash balance to fund clinical trials,
operating expenses and capital expenditures, and other statements containing the words “anticipate,” “believe,” “continue,”
“could,” “estimate,” “expect,” “intend,” “may,” “plan,” “potential,” “predict,” “project,” “should,” “target,” “would,” and similar
expressions, constitute forward-looking statements within the meaning of The Private Securities Litigation Reform Act of 1995.
Actual results may differ materially from those indicated by such forward-looking statements as a result of various important
factors, including: the uncertainties inherent in the initiation of future clinical trials, availability and timing of data from
ongoing and future clinical trials and the results of such trials, whether preliminary results from a clinical trial will be
predictive of the final results of that trial or whether results of early clinical trials will be indicative of the results of
later clinical trials, expectations for regulatory approvals, availability of funding sufficient for our foreseeable and
unforeseeable operating expenses and capital expenditure requirements and other factors discussed in the “Risk Factors” section of
our most recent filings with the Securities and Exchange Commission. In addition, any forward-looking statements included in this
press release represent our views only as of the date of this release and should not be relied upon as representing our views as of
any subsequent date. We specifically disclaim any obligation to update any forward-looking statements included in this press
release.
Contact At Bellerophon: Fabian Tenenbaum, Chief Financial Officer (908) 574-4767 At Rx Communications Group: Melody Carey (917) 322- 2571
