LUND, Sweden, April 20, 2017 /PRNewswire/ -- NeuroVive Pharmaceutical AB (Nasdaq
Stockholm: NVP, OTCQX: NEVPF) ("NeuroVive") today announced positive preclinical results demonstrating anti-fibrotic effects
with NV556, the company's preclinical compound for non-alcoholic steatohepatitis (NASH), in an additional well-validated
experimental NASH model.
NV556 has previously shown similar anti-fibrotic effects in the experimental STAM™ NASH model. Today, NeuroVive's scientists
present novel data demonstrating anti-fibrotic effects of NV5556 also in the experimental MCD NASH model, strengthening and
confirming the previous findings. In addition, in the STAM model where NASH is followed by liver cancer development, long term
treatment with NV556 was well tolerated and significantly reduced liver weight increase, indicating a reduced tumor burden.
Furthermore, there was a trend that NV556 reduced both the number and the size of tumors on the liver surface.
"We are encouraged by the confirmation of an anti-fibrotic effect of NV556 in a second well validated experimental model.
Also, the preventive effect on liver cancer development is a highly appealing observation that adds to the attractiveness of
NV556 as a possible treatment candidate for patients with progressing NASH for which there is a high unmet medical need", says
Magnus Hansson, M.D., Ph.D., Chief Medical Officer at NeuroVive.
Dr. Hansson and colleagues will present the poster titled "Anti-fibrotic effect of NV556, a sanglifehrin-based cyclophilin
inhibitor, in a preclinical model of non-alcoholic steatohepatitis1" at The International Liver Congress™ taking place in
Amsterdam, the Netherlands, 19-23 April 2017.
The International Liver Congress™ is the main annual
scientific conference of the European Association for the Study of the Liver (EASL), with about 11,000 attendees, including
scientific and medical experts from around the world, meeting to share and discuss the latest liver research findings.
About NV556
NV556 is a potent cyclophilin inhibitor in NeuroVive's Sangamide class of compounds. NV556 is undergoing preclinical
development and has so far showed an excellent safety profile. The first preclinical results for the effects of NV556 on fibrosis
development in an experimental model of NASH were received during the autumn of 2016.
In addition to NV556, NeuroVive is developing a new class of compounds with a different mode of action. This project is
complementary to NV556 and may offer an alternative treatment opportunity of NASH patients. This discovery project, titled
NVP022, utilizes NeuroVive's core competence in mitochondrial energy regulation, and NeuroVive's partner company Isomerase's
innovative chemistry capabilities are providing chemical compounds currently undergoing experimental concept testing.
About NASH
Inflammation and excess fat in the liver are symptoms of non-alcoholic steatohepatitis (NASH), a condition that causes
scarring of the liver which can lead to cirrhosis of the liver and liver cancer (hepatocellular carcinoma). There is a strong
link between NASH and other metabolic disorders, such as diabetes and obesity. The disease is common all over the world, and
about 3-5% of all Americans (roughly 15 million people) suffer from NASH,2 for which there are currently no registered treatment
options available.
1) Grönberg Alvar, Elmér Eskil, Gregory Matthew, Moss Steven, Hansson Magnus (accepted abstract)
2) Vernon G. et al. Aliment Pharmacol Ther. 2011;34(3):274-85
About NeuroVive
NeuroVive Pharmaceutical AB is a leader in mitochondrial medicine. The company is committed to the discovery and development
of medicines that preserve mitochondrial integrity and function in areas of unmet medical need. The company's strategy is to
advance drugs for rare diseases through clinical development and into the market. The strategy for projects within larger
indications outside the core focus area is out-licensing in the preclinical phase. NeuroVive enhances the value of its projects
in an organization that includes strong international partnerships and a network of mitochondrial research institutions, as well
as expertise in drug development and production.
NeuroVive has a project in early clinical phase II development for the prevention of moderate to severe traumatic brain injury
(NeuroSTAT®). NeuroSTAT has orphan drug designation in Europe and in the US. The R&D
portfolio consists of several late stage research programs in areas ranging from genetic mitochondrial disorders to cancer and
metabolic diseases such as NASH.
NeuroVive is listed on Nasdaq Stockholm, Sweden (ticker: NVP). The share is also traded on
the OTCQX Best Market in the US (OTC: NEVPF).
For investor relations and media questions, please contact:
Cecilia Hofvander, NeuroVive, Tel: +46-(0)46-275-62-21 or ir@neurovive.com
NeuroVive Pharmaceutical AB (publ)
Medicon Village, SE-223 81 Lund, Sweden
Tel: +46-(0)46-275-62-20 (switchboard)
www.neurovive.com
This information is information that NeuroVive Pharmaceutical AB (publ) is obliged to make public pursuant to the EU Market
Abuse Regulation. The information was submitted for publication, through the agency of the contact person set out above, at
08:00 a.m. CEST on 20 April 2017.
This information was brought to you by Cision http://news.cision.com
http://news.cision.com/neurovive-pharmaceutical/r/neurovive-presents-preclinical-findings-of-nv556-in-nash-showing-confirmatory-anti-fibrotic-effects,c2242676
The following files are available for download:
To view the original version on PR Newswire, visit:http://www.prnewswire.com/news-releases/neurovive-presents-preclinical-findings-of-nv556-in-nash-showing-confirmatory-anti-fibrotic-effects-300442519.html
SOURCE NeuroVive Pharmaceutical