Nature Reviews Nephrology and Pfizer Inc. discuss BET bromodomain inhibition and apabetalone as
viable drug candidates
CALGARY, May 23, 2017 /PRNewswire/ - Resverlogix Corp.
("Resverlogix" or the "Company") (TSX: RVX) today highlighted two additional works involving its lead drug, apabetalone, one
recently published by third party academics and one in the form of a patent application by Pfizer Inc. (Pfizer). The
publication, titled "Alkaline phosphatase: a novel treatment target for cardiovascular disease in CKD," is published in the
prominent journal Nature Reviews Nephrology. This article describes the mechanisms that link Alkaline Phosphatase (ALP) to
vascular calcification, inflammation, and cardiovascular disease. The Pfizer patent application was filed for the purpose of
protecting their invention of using BET-family bromodomain inhibitors as a method of increasing frataxin in the treatment of
patients with Friedreich's ataxia. Resverlogix' apabetalone, a BET bromodomain inhibitor, is specifically listed in Pfizer's
patent. The patent describes the ataxia as a rare regressive inherited disease characterized by progressive damage to the nervous
system and movement problems.
"We welcome the attention drawn to Resverlogix and apabetalone from significant industry groups such as Nature Reviews
Nephrology and Pfizer. Due to the dramatic growth of BET Bromodomain publications over the past decade, it is not surprising that
our advanced Phase 3 compound, apabetalone, is now drawing expanded attention from the global academic and pharmaceutical
communities," stated Donald McCaffrey, President and Chief Executive Officer.
Discussion on ALP and Cardiovascular Disease in Chronic Kidney Disease (CKD)
In the May, 2017 edition, Nature Reviews Nephrology published an article titled: "Alkaline phosphatase: a novel treatment
target for cardiovascular disease in CKD," (Haarhaus et al. Nature Reviews Nephrology). In addition to the discussion of the ALP
mechanism and links to disease, the authors also discuss "new drugs that target ALP, which have the potential to improve
cardiovascular outcomes without inhibiting skeletal mineralization." The article dedicates a paragraph to RVX-208
(apabetalone) and cites four different publications involving RVX-208 (apabetalone).
Findings on Frataxin Expression and Friedreich's Ataxia
Recently, Pfizer applied for a patent titled: "Regulators of Frataxin" (WO 2017/037567 A1), their invention relates to the
expression of frataxin by utilizing BET-bromodomain inhibitors. The purpose of the invention is for the potential treatment of a
rare disease called Friedreich' ataxia (FA). RVX-208 (apabetalone) was listed as a potentially effective agent against this
disease which is present in about 1 in 50,000 people. The ataxia of Friedreich's ataxia occurs from the degeneration of nerve
tissue in the spinal cord. Symptoms usually begin between 5 to 15 years of age, leading to wheelchair requirements and can
eventually lead to early death often related to cardiovascular disease.
About Resverlogix
Resverlogix is developing apabetalone (RVX-208), a first-in-class, small molecule that is a selective BET (bromodomain and
extra-terminal) inhibitor. BET bromodomain inhibition is an epigenetic mechanism that can regulate disease-causing genes.
Apabetalone is the first and only BET inhibitor selective for the second bromodomain (BD2) within the BET protein called BRD4.
This selective inhibition of apabetalone on BD2 produces a specific set of biological effects with potentially important benefits
for patients with diseases such as high-risk cardiovascular disease (CVD), diabetes mellitus (DM), chronic kidney disease,
dialysis, Alzheimer's disease, Orphan diseases, and peripheral artery disease, while maintaining a well described safety profile.
Apabetalone is the only selective BET bromodomain inhibitor in human clinical trials. Apabetalone is currently in a Phase 3
trial, BETonMACE, in high-risk CVD patients with type 2 DM and low high-density lipoprotein (HDL), and in a Phase 2a kidney
dialysis trial designed to evaluate biomarker changes and safety parameters with apabetalone in up to 30 patients with end-stage
renal disease treated with hemodialysis.
Resverlogix common shares trade on the Toronto Stock Exchange (TSX: RVX).
For further information please visit www.resverlogix.com.
Follow us on Twitter: @Resverlogix_RVX (https://twitter.com/resverlogix_rvx), or on our blog at http://www.resverlogix.com/blog
For further information please contact:
Investor Relations
Email: ir@resverlogix.com
Phone: 403-254-9252
This news release may contain certain forward-looking information as defined under applicable Canadian securities
legislation, that are not based on historical fact, including without limitation statements containing the words "believes",
"anticipates", "plans", "intends", "will", "should", "expects", "continue", "estimate", "forecasts" and other similar
expressions. In particular, this news release includes forward looking information relating to the potential role of apabetalone
in the treatment of CVD, DM, chronic kidney disease , end-stage renal disease treated with hemodialysis,
Alzheimer's disease, Alkaline phosphatase (ALP), vascular calcification, inflammation, Friedreich's ataxia, expression
of frataxin, and Orphan diseases. Our actual results, events or developments could be materially different from those
expressed or implied by these forward-looking statements. We can give no assurance that any of the events or expectations will
occur or be realized. By their nature, forward-looking statements are subject to numerous assumptions and risk factors including
those discussed in our Annual Information Form and most recent MD&A which are incorporated herein by reference and are
available through SEDAR at www.sedar.com
. The forward-looking statements contained in this news release are expressly qualified by this cautionary statement and are
made as of the date hereof. The Company disclaims any intention and has no obligation or responsibility, except as required by
law, to update or revise any forward-looking statements, whether as a result of new information, future events or
otherwise.
SOURCE Resverlogix Corp.