Acorda Receives Refusal to File Letter from FDA for INBRIJA™ (CVT-301, levodopa inhalation powder) New Drug
Application
Acorda Therapeutics, Inc. (Nasdaq: ACOR) today announced that it received a Refusal to File (RTF) letter from the U.S. Food and
Drug Administration (FDA) regarding its New Drug Application (NDA) for INBRIJA. INBRIJA is an investigational treatment for
symptoms of OFF periods in people with Parkinson’s disease taking a carbidopa/levodopa regimen.
Upon its preliminary review, FDA determined that the NDA, submitted on June 26, 2017, was not sufficiently complete to permit a
substantive review. FDA specified two reasons for the RTF: first, the date when the manufacturing site would be ready for
inspection, and, second, a question regarding the submission of the drug master production record. FDA also requested additional
information at resubmission, which was not part of the basis for the RTF.
The Company will seek immediate guidance, including a Type A meeting with the FDA, to respond to the issues, which it believes
are addressable, and to seek clarification of what additional information will be required. The FDA has not requested or
recommended additional clinical efficacy or safety studies.
“We will work with the FDA as quickly as possible to address the open issues and to clarify the path to successfully re-file our
application,” said Ron Cohen, M.D., Acorda's President and CEO. “We remain confident in INBRIJA’s data package and its promise as
an important new therapy for people with Parkinson's disease. We see tremendous long-term value in its solid clinical profile,
significant commercial opportunity and strong IP, and we remain focused on working to bring patients this important new
therapy.”
About Acorda Therapeutics
Founded in 1995, Acorda Therapeutics is a biopharmaceutical company focused on developing therapies that restore
function and improve the lives of people with neurological disorders. Acorda has a pipeline of novel neurological therapies
addressing a range of disorders, including Parkinson’s disease and multiple sclerosis. Acorda markets three FDA-approved
therapies, including AMPYRA® (dalfampridine) Extended Release Tablets, 10 mg.
Forward-Looking Statement
This press release includes forward-looking statements. All statements, other than statements of historical facts, regarding
management's expectations, beliefs, goals, plans or prospects should be considered forward-looking. These statements are subject to
risks and uncertainties that could cause actual results to differ materially, including: the ability to realize the benefits
anticipated from the Biotie and Civitas transactions, among other reasons because acquired development programs are generally
subject to all the risks inherent in the drug development process and our knowledge of the risks specifically relevant to acquired
programs generally improves over time; the ability to successfully integrate Biotie’s operations into our operations; we may need
to raise additional funds to finance our operations and may not be able to do so on acceptable terms; our ability to successfully
market and sell Ampyra (dalfampridine) Extended Release Tablets, 10 mg in the U.S., which will likely be materially adversely
affected by the recently announced court decision in our litigation against filers of Abbreviated New Drug Applications to market
generic versions of Ampyra in the U.S.; the risk of unfavorable results from future studies of Inbrija (CVT-301, levodopa
inhalation powder), tozadenant or from our other research and development programs, or any other acquired or in-licensed programs;
we may not be able to complete development of, obtain regulatory approval for, or successfully market Inbrija, tozadenant, or any
other products under development; third party payers (including governmental agencies) may not reimburse for the use of Ampyra,
Inbrija or our other products at acceptable rates or at all and may impose restrictive prior authorization requirements that limit
or block prescriptions; the occurrence of adverse safety events with our products; failure to maintain regulatory approval of or to
successfully market Fampyra outside of the U.S. and our dependence on our collaborator Biogen in connection therewith; competition;
failure to protect our intellectual property, to defend against the intellectual property claims of others or to obtain third party
intellectual property licenses needed for the commercialization of our products; and failure to comply with regulatory requirements
could result in adverse action by regulatory agencies.
These and other risks are described in greater detail in our filings with the Securities and Exchange Commission. We may not
actually achieve the goals or plans described in our forward-looking statements, and investors should not place undue reliance on
these statements. Forward-looking statements made in this press release are made only as of the date hereof, and we disclaim any
intent or obligation to update any forward-looking statements as a result of developments occurring after the date of this press
release.
Acorda Therapeutics, Inc.
Investors/Analysts:
Felicia Vonella, 914-326-5146
Investor Relations
fvonella@acorda.com
or
Media:
Tierney Saccavino, 914-326-5104
Corporate Communications
tsaccavino@acorda.com
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