ANAVEX®2-73 Shown to Protect and Repair Myelin Forming Cells
NEW YORK, Oct. 27, 2017 (GLOBE NEWSWIRE) -- Anavex Life Sciences Corp. (Anavex or the Company) (Nasdaq:AVXL), a
clinical-stage biopharmaceutical company developing differentiated therapeutics for the treatment of neurodegenerative and
neurodevelopmental diseases including Alzheimer’s disease, other central nervous system (CNS) diseases, pain and various types of
cancer, today announced additional data from a preclinical study of ANAVEX®2-73 related to multiple sclerosis. The data was
presented in an oral presentation by lead investigator, Robert Lisak, MD, Professor of Neurology at Wayne State University School
of Medicine, at the 7th Joint ECTRIMS-ACTRIMS Meeting MSPARIS2017.
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Remyelination: from biology to clinical trials |
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Sigma 1 receptor agonists as potential protective and reparative therapy in
multiple sclerosis |
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October 27, 2017 |
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2:52 pm ECT |
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Hall B, Le Palais des Congrès de Paris |
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2 Place de la Porte Maillot |
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75017 Paris, France |
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“A unique feature of ANAVEX2-73, compared to another sigma-1 receptor agonist we studied, is that ANAVEX2-73
accelerates the maturation of oligodendrocyte precursor cells (OPC) to oligodendrocytes (OL),” said Dr Robert P. Lisak. “This is an
important feature since OPCs can replace lost OLs by maturing into new potential myelin-producing cells. In other words, ANAVEX2-73
might promote remyelination. Further data also demonstrates that ANAVEX2-73 provides protection for OL, OPCs, as well as central
nervous system neurons in addition to helping repair by increasing OPC proliferation and maturation in tissue culture.“
“These findings provide additional evidence for the neuroprotective and neurorestorative effects of ANAVEX2-73,
as well as further validating the mechanism of our target,” said Christopher U. Missling, PhD, President and Chief Executive
Officer of Anavex.
About Multiple sclerosis
Multiple sclerosis (MS) is a chronic autoimmune disease that causes damage to nerve fibers in the central nervous system (CNS),
including the brain, spinal cord and optic nerve. This can disrupt communication between the CNS and other parts of the body,
resulting in a wide range of physical and cognitive symptoms such as muscle weakness, visual loss, poor balance, chronic pain,
tremors, short-term memory loss and other difficulties associated with dementia.
About Anavex Life Sciences Corp.
Anavex Life Sciences Corp. (Nasdaq:AVXL) is a publicly traded biopharmaceutical company dedicated to the development of
differentiated therapeutics for the treatment of neurodegenerative and neurodevelopmental diseases including Alzheimer’s disease,
other central nervous system (CNS) diseases, pain and various types of cancer. Anavex’s lead drug candidate,
ANAVEX®2-73, recently completed successfully a Phase 2a clinical trial for Alzheimer’s disease. ANAVEX®2-73
is an orally available drug candidate that restores cellular homeostasis by targeting sigma-1 and muscarinic receptors. Preclinical
studies demonstrated its potential to halt and/or reverse the course of Alzheimer’s disease. It has also exhibited anticonvulsant,
anti-amnesic, neuroprotective and anti-depressant properties in animal models, indicating its potential to treat additional CNS
disorders, including epilepsy. The Michael J. Fox Foundation for Parkinson’s Research has awarded Anavex a research grant to
develop ANAVEX®2-73 for the treatment of Parkinson’s disease to fully fund a preclinical study, which could justify
moving ANAVEX®2-73 into a Parkinson’s disease clinical trial. ANAVEX®3-71, also targeting sigma-1 and M1 muscarinic
receptors, is a promising preclinical drug candidate demonstrating disease modifications against the major Alzheimer’s hallmarks in
transgenic (3xTg-AD) mice, including cognitive deficits, amyloid and tau pathologies, and also with beneficial effects on
neuroinflammation and mitochondrial dysfunctions. Further information is available at www.anavex.com. You can also connect with the
company on Twitter, Facebook and LinkedIn.
Forward-Looking Statements
Statements in this press release that are not strictly historical in nature are forward-looking statements. These statements are
only predictions based on current information and expectations and involve a number of risks and uncertainties. Actual events or
results may differ materially from those projected in any of such statements due to various factors, including the risks set forth
in the Company’s most recent Annual Report on Form 10-K filed with the SEC. Readers are cautioned not to place undue reliance on
these forward-looking statements, which speak only as of the date hereof. All forward-looking statements are qualified in their
entirety by this cautionary statement and Anavex Life Sciences Corp. undertakes no obligation to revise or update this press
release to reflect events or circumstances after the date hereof.
For Further Information:
Anavex Life Sciences Corp.
Research & Business Development
Toll-free: 1-844-689-3939
Email: info@anavex.com
Investors & Media:
Clayton Robertson
The Trout Group
(646) 378-2900
crobertson@troutgroup.com
