Toronto, Ontario (FSCwire) - Theralase Technologies Inc.
(“Theralase®” or the “Company”) (TSXV: TLT)
(OTCQX: TLTFF), a leading biotech company focused on the commercialization of medical lasers to
eliminate pain and the development of Photo Dynamic Compounds (“PDCs”) to destroy cancer has announced that it
has validated its new anti-cancer vaccine in an additional animal cancer model for colorectal cancer.
The new anti-cancer vaccine was validated in a subcutaneous, colorectal cancer cell (CT.26 WT) mouse model,
demonstrating that Theralase’s new anti-cancer vaccine is not solely limited to GlioBlastoma Multiforme (“GBM”)
brain cancer cells (previously validated in a Rat Glioma (“RG2”) model), but is also able to be adapted to other
types of cancer cell lines, in which the animal’s immune system is stimulated and subsequently programmed to hunt, recognize and
destroy cancer cells of specific types.
In Theralase conducted research, it was demonstrated that the new anti-cancer vaccine was able to increase well established
biomarkers of the immunological destruction of cancer cells, such as increased Adenosine TriPhosphate (“ATP”)
release and increased calreticulin surface expression for colorectal cancer cells.
Extracellular ATP quantification:
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Cell surface expression of calreticulin was increased by 87% over control:
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To evaluate the new anti-cancer vaccine in animals, mice were vaccinated and then implanted with colorectal cancer cells
utilising an established model of colorectal carcinoma. Vaccinated mice were able to survive 58% longer on average than
non-vaccinated mice. This increase in survival was due to a significant growth delay in tumor size.
Survival analysis after tumor induction:
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Tumour volume after tumour induction:
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Excluding skin cancers, colorectal cancer is the third most common cancer diagnosed in both men and women in the United
States. The American Cancer Society’s estimates that the number of colorectal cancer cases in the United States for 2017 are:
- 95,520 new cases of colon cancer
- 39,910 new cases of rectal cancer
Colorectal cancer is the third leading cause of cancer-related deaths in women in the United States and the second leading
cause in men. It is expected to cause about 50,260 deaths in 2017.
Mark Roufaiel, Ph.D., Research Scientist, Theralase stated, “The latest data supports our understanding that the new
anti-cancer vaccine approach developed by Theralase is able to induce a potent, anti-tumour, immune response that can
significantly delay recurrence and progression of various metastatic tumors, leading to a significant increase in animal
survival. This new research demonstrates that the Theralase anti-cancer vaccine approach is not limited to any specific type of
cancer and is thus able to be adapted to be effective for the treatment of various cancers.”
Manjunatha Ankathatti Munegowda, Ph.D., DVM, Research Scientist, Theralase, stated that, “The Theralase anti-cancer vaccine
has now demonstrated significant therapeutic benefit in both an aggressive RG2 GBM brain cancer animal model and in a colorectal
tumor animal model. This finding supports the understanding that this vaccine has utility for multiple cancer indications,
irrespective of the presence of genetic mutations, physical location of the cancer or the origin of the disease. As an
anti-cancer vaccine that is intramuscularly injected into an animal, it is able to directly stimulate the immune system to hunt,
recognize and destroy cancer cells of a specific type and in doing so, increase the animal’s quality of life and overall
survival.”
Arkady Mandel, M.D., Ph.D., D.Sc., Chief Scientific Officer, Theralase stated: “The scientific and clinical objectives were
clearly defined by our scientific research team, prior to undertaking a project of this magnitude; however, there was always one
critical question that remained, ‘How do we systematically address the mutations that are unique to an individual patient’s
tumour, but at the same time develop a anti-cancer vaccine that has the ability to directly influence several amplification
pathways to stimulate a whole body anti-cancer immune response in patients with various forms of cancer?’ I’m pleased to report
that we were able to answer this question, in animals, in the form of Theralase’s anti-cancer vaccine, which has now been
validated in two distinct animal cancer models; specifically: GBM brain cancer and colorectal cancer and both have demonstrated a
significant increase in overall survival for two distinct animal species (mice and rats). The next objective of our research will
be to validate whether the significant results we have observed in our animal models is able to be successfully translated to
humans. The hope is that Theralase’s anti-cancer vaccine will demonstrate significant clinical activity in humans, as well, with
improvements in patient outcomes versus current standards of care. As we advance our scientific research, we are steadily
overcoming the obstacles on our road to success, with the realization that fully personalized anti-cancer vaccines for numerous
human cancers are within our grasp and are quickly becoming a reality.”
Roger Dumoulin-White, P.Eng., President and CEO of Theralase stated that, “The additional validation of the new
anti-cancer vaccine, in colorectal cancer, only emboldens the entire Company that the path we have chosen is the correct one and
as a result we all look forward to making a significant stride forward in the war on cancer. I look forward to advancing Dr.
Mandel’s and his team’s cutting-edge scientific research to the clinic, in the form of a Phase Ib clinical study and successfully
demonstrating these significant results clinically in humans.”
About Theralase Technologies Inc.
Theralase Technologies Inc. (“Theralase®” or the “Company”) (TSXV:
TLT) (OTCQX: TLTFF) in its Therapeutic Laser Technology (“TLT”)
Division designs, manufactures, markets and distributes patented super-pulsed laser technology indicated for the treatment of
chronic knee pain, and in off-label use, the elimination of pain, reduction of inflammation and dramatic acceleration of tissue
healing for numerous nerve, muscle and joint conditions. Theralase’s Photo Dynamic Therapy (“PDT”) Division
researches and develops specially designed molecules called Photo Dynamic Compounds (“PDCs”), which have
demonstrated an ability to localize to cancer cells and then when laser light activated, effectively destroy them.
Additional information is available at www.theralase.com and www.sedar.com .
This news release contains "forward-looking statements" which reflect the current expectations
of management of the Corporation’s future growth, results of operations, performance and business prospects and opportunities.
Such statements include, but are not limited to, statements regarding the proposed use of proceeds. Wherever possible, words such
as "may", "would", "could", “should”,
"will", "anticipate", "believe", "plan",
"expect", "intend", "estimate", "potential for" and similar
expressions have been used to identify these forward-looking statements. These statements reflect management's current beliefs
with respect to future events and are based on information currently available to management. Forward-looking statements involve
significant risks, uncertainties and assumptions. Many factors could cause the Corporation’s actual results, performance or
achievements to be materially different from any future results, performance or achievements that may be expressed or implied by
such forward-looking statements; including, without limitation, those listed in the filings made by the Corporation with the
Canadian securities regulatory authorities (which may be viewed at www.sedar.com). Should one
or more of these risks or uncertainties materialize, or should assumptions underlying the forward looking statements prove
incorrect, actual results, performance or achievements may vary materially from those expressed or implied by the forward-looking
statements contained in this news release. These factors should be considered carefully and prospective investors should not
place undue reliance on the forward-looking statements. Although the forward-looking statements contained in the news release are
based upon what management currently believes to be reasonable assumptions, the Corporation cannot assure prospective investors
that actual results, performance or achievements will be consistent with these forward-looking statements. The Corporation
disclaims any intention or obligation to revise forward-looking statements whether as a result of new information, future
developments or otherwise except as required by law. All forward-looking statements are expressly qualified in their entirety by
this cautionary statement.
Neither TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in the policies of
the TSX Venture Exchanges) accepts responsibility for the adequacy or accuracy of this release.
For More Information:
Roger Dumoulin-White
President & CEO
1.866.THE.LASE (843-5273) ext. 225
416.699.LASE (5273) ext. 225
rwhite@theralase.com
www.theralase.com
To view this press release as a PDF file, click onto the following link:
public://news_release_pdf/Theralase11222017_1.pdf
Source: Theralase Technologies Inc. (TSX Venture:TLT, OTCQX:TLTFF, FWB:TTX)
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