CAMBRIDGE, Mass., March 8, 2019 /PRNewswire/ -- Leap
Therapeutics, Inc. (Nasdaq: LPTX), a biotechnology company focused on developing targeted and immuno-oncology therapeutics, today
announced the Company will be presenting at the Society of Gynecologic Oncology 2019 Annual Meeting on Women's Cancer, being held
March 16-19, 2019 in Honolulu, HI.
About the DKN-01 P204 clinical trial
The P204 study is a Phase 2 basket study of DKN-01 as both a monotherapy and in combination with paclitaxel in
patients with advanced endometrioid unterine (EEC) and endometrioid ovarian (EOC) cancers. These malignancies have a percentage
of patients with mutations in the Wnt pathway. The study consists of four dosing groups and will enroll up to 94 patients using a
Simon 2-Stage design in each group. The primary objective in each independent study group is to determine the overall response.
Secondary objectives include measures of efficacy such as overall survival and progression free survival, and to evaluate the
safety of the treatment regimen.
Leap Presentation Details:
Abstract Number: 65
Title: Safety and efficacy of a DKK1 inhibitor (DKN-01) as monotherapy or in combination with
paclitaxel in patients with Wnt activated recurrent gynecologic malignancies
Session Title: Oral Featured Poster Session II: Trials, Basic Science and Translational Science
Date: Monday, March 18
Time: 6:00 – 7:00 PM GMT
Location: Hawaii Convention Center 313AB
About Leap Therapeutics
Leap Therapeutics (Nasdaq:LPTX) is focused on developing targeted and immuno-oncology therapeutics. Leap's most
advanced clinical candidate, DKN-01, is a humanized monoclonal antibody targeting the Dickkopf-1 (DKK1) protein, a Wnt pathway modulator. DKN-01 is in clinical trials in patients with esophagogastric,
hepatobiliary, gynecologic, and prostate cancers. Leap's second clinical candidate, TRX518, is a humanized GITR agonist
monoclonal antibody designed to enhance the immune system's anti-tumor response that is in advanced solid tumor studies. For more
information about Leap Therapeutics, visit http://www.leaptx.com or our public filings with the SEC that are available via EDGAR at http://www.sec.gov or via https://www.leaptx.com/investors.
FORWARD LOOKING STATEMENTS
This press release contains forward-looking statements within the meaning of Section 27A of the Securities Act of 1933,
Section 21E of the Securities Exchange Act of 1934 and the Private Securities Litigation Reform Act of 1995, which involve risks
and uncertainties. These statements include statements regarding Leap's intended use of proceeds from the offering, Leap's
expectations with respect to the development and advancement of DKN-01, TRX518, and other programs, including the initiation,
timing and design of future studies, enrollment in future studies, business development, and other future expectations, plans and
prospects. Leap has attempted to identify forward looking statements by such terminology as ''believes,'' ''estimates,''
''anticipates,'' ''expects,'' ''plans,'' ''projects,'' ''intends,'' ''may,'' ''could,'' ''might,'' ''will,'' ''should,'' or other
words that convey uncertainty of future events or outcomes to identify these forward-looking statements. Although Leap believes
that the expectations reflected in such forward-looking statements are reasonable as of the date made, forward-looking statements
are subject to known and unknown risks, uncertainties and other factors that could cause actual results to differ materially from
our expectations. Such risks and uncertainties include, but are not limited to: the accuracy of our estimates regarding expenses,
future revenues, capital requirements and needs for financing; the ability to complete a financing or form business development
relationships to fund our expenses; the outcome, cost, and timing of our product development activities and clinical trials; the
uncertain clinical development process, including the risk that clinical trials may not have an effective design or generate
positive results; our ability to obtain and maintain regulatory approval of our drug product candidates; our plans to research,
develop, and commercialize our drug product candidates; our ability to achieve market acceptance of our drug product candidates;
unanticipated costs or delays in research, development, and commercialization efforts; the applicability of clinical study
results to actual outcomes; the size and growth potential of the markets for our drug product candidates; our ability to continue
obtaining and maintaining intellectual property protection for our drug product candidates; and other risks. Detailed information
regarding factors that may cause actual results to differ materially will be included in Leap Therapeutics' periodic filings with
the SEC, including Leap Therapeutics' Annual Report on Form 10-K for the fiscal year ended December 31,
2017 that Leap filed with the SEC on February 23, 2018 and Leap Therapeutics' Quarterly
Reports on Form 10-Q for each of the quarters ended March 31, 2018, June 30,
2018 and September 30, 2018 that Leap filed with the SEC on each of May 11, 2018, August 8, 2018 and November 9, 2018,
respectively. These statements are only predictions and involve known and unknown risks, uncertainties, and other factors. Any
forward looking statements contained in this release speak only as of its date. We undertake no obligation to update any
forward-looking statements contained in this release to reflect events or circumstances occurring after its date or to reflect
the occurrence of unanticipated events.
CONTACT:
Douglas E. Onsi
Chief Financial Officer
Leap Therapeutics, Inc.
donsi@leaptx.com
617-714-0360
Argot Partners
Investor Relations
Heather Savelle
212-600-1902
heather@argotpartners.com
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SOURCE Leap Therapeutics, Inc.