Biosign Technologies Inc BITKF

NEWS!

[Lucy1]

BIOTECH HOLDINGS RECEIVES SECOND SUCANON ORDER FROM WAL-MART Vancouver, B.C., April 27, 2005 - Robert Rieveley, President of Biotech Holdings (the “Company”, TSX-V: BIO; OTC BB: BIOHF) announced today that the Company has received its second purchase order for its Sucanon diabetes drug from Wal-Mart. “I am pleased to report that we have now received a second order from Wal-Mart Stores in Mexico. This order is from Wal-Mart’s Supercenter stores division. This order increases to 137 the total number of Wal-Mart stores in Mexico to which we are supplying Sucanon. There are 89 Wal-Mart Supercenter stores and 48 Superama stores. Both divisions have stores in all regions of Mexico,” Mr. Rieveley said. “We will be announcing shortly the starting date for our television advertising, co-ordinated with Sucanon availability in Wal-Mart stores nationally across Mexico,” Mr. Rieveley said. If you would you would like to be added to Biotech Holdings’ email list for future news updates or summary clinical materials, please click here: https://www.biotechltd.com/info.asp Biotech Holdings Ltd.’s head office is in Richmond, British Columbia. Biotech Holdings’ shares trade on the Over the Counter Bulletin Board in the United States (BIOHF.OB) and on the TSX Venture Exchange in Canada (BIO.V). For inquiries, contact Austin Rand at Biotech Holdings Ltd., 1 888 216 1111 (toll-free), 8:00 a.m. to 4 p.m. Pacific time, or by e-mail at [e-mail]. For background information and current stock quotations, please visit Biotech's website at www.biotechltd.com. On behalf of the Board of Directors: /s/ Robert B. Rieveley, President and Director. The TSX Venture Exchange has not reviewed and does not accept responsibility for the adequacy or the accuracy of this release.