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Cotinga Pharmaceuticals Inc COTQF

Cotinga Pharmaceuticals Inc is a clinical-stage biopharmaceutical company. The company's lead clinical candidate, COTI-2, is an oral small molecule targeting p53, a tumor suppressor gene that is mutated in over 50% of all cancers, and the company's second clinical candidate, COTI-219, is a novel oral small molecule compound targeting the mutant forms of KRAS with such mutations occurring in up to 30% of all cancers.


GREY:COTQF - Post by User

Post by Cotitwoon Sep 10, 2018 11:25am
170 Views
Post# 28590212

M D Anderson

M D AndersonI have not given up Hope with this company. We need a break. and hopefully it will come from M D Anderson. We have been waiting for them to start the Combination study with Coti 2 and Cisplatin for about 5 weeks now
I think once it starts we should see some very positive results and there are eyes waiting for results
All the clinical studies which you can find on there web site showed positive results in all cases
There is one diagram showing four of 9 species literally cancer free after 2 months. So its a clinical study you say
Well what they did is took FDA approved cancer drugs that people take every day of there lives and compared it to Coti2 and got similar results. When they combined it with Coti2 in every instance they approved the results dramatically 
I spoke with the former CSO of the company who is still very positive on COT and he feels that a dosage of 0.75 milligrams could be the dosage where it could be beneficial to the patients
Were starting at 0.5 mgs and go up from there so we could see results rather quickly
Each cohort starts at 0.5 mgs for 3 weeks along with a dosage of Cisplatin. After 3 weeks they have testing done and continue on the same dose
Once 3 cohorts complete there 3 weeks  successfuly they start the next 3 cohorts at a higher dosage [ i heard 1mg ] and go from there.
So come on MDACC lets get this study going
im open to questions and criticism
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