NewsNew Preclinical Research Presented at AACR 2019 Reveals Unique Anti-Cancer Mechanism of Action Underscoring IMVs Immunotherapy Program April 3, 2019 at 8:00 AM EDT DARTMOUTH, Nova Scotia--(BUSINESS WIRE)--Apr. 3, 2019--IMV Inc.(Nasdaq: IMV; TSX: IMV), a clinical stage immuno-oncology corporation, today announced that preclinical research presented at theAmerican Association for Cancer Research(AACR) Annual Meeting 2019demonstrated how the mechanism of action (MOA) of IMVs proprietary DPX technology can enhance a broad spectrum of immune cell infiltration into tumors, which included T cells, Natural Killer (NK) cells, and macrophages. Analyses also revealed the differentiated characteristics of the immune cell responses and the potential implications for enhanced anti-tumor efficacy. The new preclinical data shared at this years AACR Annual Meeting provides greater insight into the unique mechanism of our immunotherapy programs, saidMarianne Stanford, Vice President, Researchat IMV. These data demonstrate our commitment to fully understanding how our platform impacts our product candidates, which in turn informs our clinical program designs and ability to identify patient needs that are more likely to benefit from our approach. In the poster titled,T-distributed stochastic neighbor embedding (t-SNE) analysis of tumor infiltrating lymphocytes after treatment with a T cell activating therapy identifies a unique population of recruited CD8+ T cells and novel options for combination immunotherapy, IMV researchers used specialized data analytics to examine how DPX-based agents, when combined with cyclophosphamide (CPA), induced T cells to infiltrate tumors and attack cancerous cells. The study closely examined the types of immune cell responses and how and why they were able to affect disease. The data indicated that this approach stimulated the infiltration of a broad base of immune cells into tumors, including T cells, NK cells, and macrophages. The specific T cell population that moved into tumors could be grouped based on the co-expression of different checkpoint molecules such as PD-1 and Tim-3. However, those stimulated to infiltrate tumors generally did not express CTLA-4 (a protein found on T cells that inhibits the immune response). Researchers also found that combining DPX/CPA treatments with a CTLA-4-blocking antibody increased efficacy in controlling tumor growth in the animal models. The data suggested that this result was due to the antibodies acting on T cells present in the tumors, rather than those induced by treatment. This finding contrasts previously published studies with anti-PD-1 combinations in which treatment directly enhanced DPX-induced T cell responses. We believe there is a need for more targeted immunotherapy approaches and this work is another important step for us toward achieving this goal, saidFrederic Ors, Chief Executive Officer, at IMV. This is a new frontier in immuno-oncology drug development, and Im proud of the work our team has done and the potential it represents to, ultimately, improve treatments for patients. IMVs current clinical program includes multiple phase 2 studies assessing the safety and efficacy of its lead candidate, DPX-Survivac, in combination with mCPA and Mercks checkpoint inhibitor, Keytruda. About IMV IMV Inc.is a clinical stage biopharmaceutical company dedicated to making immunotherapy more effective, more broadly applicable, and more widely available to people facing cancer and other serious diseases. IMV is pioneering a new class of immunotherapies based on the Companys proprietary drug delivery platform. This patented technology leverages a novel mechanism of action that enables the programming of immune cellsin vivo,which are aimed at generating powerful new synthetic therapeutic capabilities. IMVs lead candidate, DPX-Survivac, is a T cell-activating immunotherapy that combines the utility of the platform with a target: survivin. IMV is currently assessing DPX-Survivac as a monotherapy in advanced ovarian cancer, as well as a combination therapy in multiple clinical studies with Merck. Connect atwww.imv-inc.com.