RE:Flu virus augment vaccines"One stratregy to enhance T cell priming / tumor immunogenicity is to increase the amount of tumor neoantigens available to T cell", which has been demonstrated by ONCY's pelareorep, and in doing so, reversing T-cell exhaustion.
https://www.researchgate.net/publication/376712603_Overcoming_Resistance_Mechanisms_to_Immune_Checkpoint_Inhibitors_Leveraging_the_Anti-Tumor_Immune_Response