Oncolytics Biotech Inc ONCY

Spontaneous tumor regression following COVID-19 vaccination

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" ..  we observed a shift in the TIME composition from myeloid predominant to lymphocytic predominant. Fractions of immune suppressive cells, represented by M2-macrophages, regulatory T cells, and cancer-associated fibroblasts, were higher in prevaccination samples than in postvaccination samples, which align with previous literature showing that immune suppressive cells are associated with immune evasion and worse prognosis in cancer. Finally, dysfunctional and exhausted T cells, represented by expression for TIM3, were also more prevalent in the pre-vaccination samples, whereas TIGIT expression in T cells was higher after vaccination and may be associated with T-cell activation."


https://jitc.bmj.com/content/10/3/e004371

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" ... COVID-19 vaccine induced systemic immune activation and led to a robust and persistent anticancer response, represented by radiological tumor shrinkage and an ‘anticancer’ TIME composition. "

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guess someone should let them know about pela: Challenges remain to select a virus capable of replicating in cancer cells, generating an immune-activating microenvironment and leading to antigen spreading [58]. The rapid progress in the development and worldwide use of mRNA vaccines increases the chances of using mRNA against SARS-CoV-2 for cancer patients. Although methods to optimize the

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Well ,unless you have kept your head buried in the sand, like your post seems to have done, any described challenges have been met by ONCY's pelareorep, as documented on this message board many times over.