RE:skyhigh re 4050 and francois/sah1
For now, I can't see that have sufficient ressources to bring PBI-4050 alone in a larger application.
It will have to be partnered with a bigger player. PLI may have $ 20M in the bank account, but they already have to devellop orphan drug from the plasma.
A positive phase I/bII should trigger a partnership.
As for the phase I safety trial, they shouldn'be too much problem, as PBI-4050 is in the same family of PBI-1402, wich was successfull in phase I.