Interestinghttps://www.annalsofoncology.org/article/S0923-7534(19)32244-6/fulltext
Conclusions
Careful consideration should be given to the decision to terminate a study for futility, as futility calculations do not always get it right and can represent an inadequate estimate of the final trial results. Given the consequences of early termination, it may be reasonable to evaluate how the termination criteria behaved over time. Decisions to terminate a study should always be made after due consideration of all aspects of the study, including toxicity and other endpoints.