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Antibe Therapeutics Inc(Pre-Merger) T.ATE


Primary Symbol: ATBPF

Antibe Therapeutics Inc. is a clinical-stage biotechnology company. The Company is leveraging its hydrogen sulfide (H2S) platform to develop therapies to target inflammation arising from a range of medical conditions. The Company’s pipeline includes assets that seek to overcome the gastrointestinal ulcers and bleeding associated with nonsteroidal anti-inflammatory drugs (NSAIDs). Its lead drug, otenaproxesul, is in clinical development as an alternative to opioids and NSAIDs for acute pain. Its second pipeline drug, ATB-352, is being developed for a specialized pain indication. The Company also focuses on inflammatory bowel disease (IBD). Otenaproxesul combines a moiety that releases hydrogen sulfide with naproxen, a non-steroidal, anti-inflammatory drug. ATB-352 is an H2S-releasing derivative of ketoprofen, a potent NSAID commonly prescribed for acute pain. Its IBD candidates are being designed to maintain the efficacy, safety, and pharmacokinetic properties of ATB-429.


GREY:ATBPF - Post by User

Comment by MrMugsyon Dec 05, 2021 11:18am
230 Views
Post# 34199859

RE:RE:New CEO

RE:RE:New CEO
JPkatz wrote:
That would be Sweet if true!! Only problem is so much damage has been done by Dan... Not sure if this can be salvaged at this point.


The way I look at it ... regardless of who was the CEO ... we never would have made it to P3 for chronic pain (we now know that).
- no lowest dose determined for chronic
- liver issues over extended use were unexpected

The above two items are key in discussing today's shares price.  Try figuring out blame based on those items and I don't think any CEO could have managed the share price differently.

Regardless - I assume Dan isn't retiring until we get a first win (if we get a first win).  That's when I see a potential retirement and a different CEO needed to move an H2S development company forward - all cashed up and ready to go.  It's just simpler to assume it that way w.r.t. Dan. 

Also, I still think Dan has more than 70% of the votes on his side.

Can this company be salvaged?  I sure hope so.  Acute has risk but it's a simpler path forward.  We also need acute to talk about a chronic regimen.  2022 will be a busy year and critical in determining how resilent our H2S platform really is.

Is acute the faster way to market?
Are all avenues still in play and will acute lead to a better understanding of a chronic regimen?
If chronic just can't move forward - can we be the flare-up specialists?

I still think there are many ways to play chronic but that's just my personal opinion ...

For example - let's look at IBD for chronic conditions (instead of Chronic Pain for the moment) ... a different example but it's the same thought process I used for chronic pain.

If we have an IBD drug selected in early 2022 and we also have Mesalamine available  ... surely there's different potential regimen's out there that allows us to supply bursts of active ingedient with H2S, straight active drug (Mesalamine without H2S) and sugar pills ... in some manner that allows for safer and effective ways to deal with chronic IBD.  Maybe you don't even need straight Mesalamine in the regimen and it can be accomplished with varying doses of the new IBD drug.  It's just a matter of finding the right regimen.  Otherwise ... we only offer IBD in bursts to contend with flare-ups in crohn's and colitis.

Lots to determine and it's the CEO that needs to set the right path forward from here.  Don't think he could have done anything to save chronic in it's present state.  All a learning process and we have interesting ways to pivot.

IMO

Good Luck All !



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