Neutralizing O2- to reduce ROS ...I see some interesting work to tame superoxides. Wonder if this can be incorporated into future H2S drug design for chronic conditions.
"To reduce cellular oxidative stress caused by overproduction of superoxide, we developed a compound that reacts with O2.− to release a persulfide (RSSH), a type of reactive sulfur species related to the gasotransmitter hydrogen sulfide (H2S)."
"Both SOPD-NAC and SOPD-Pep delivered persulfides/H2S to H9C2 cardiomyocytes and lowered ROS levels as confirmed by quantitative in vitro fluorescence imaging studies."