Antibe Therapeutics Inc(Pre-Merger) T.ATE

Time to Market for H2S Pipeline

[mstrmnd]

That's all that matters.

P2b/3a for OA to prove safety and efficacy for chronic use will be time and resource intensive.

P2b/3a for Post-Operative Pain for 10-14-day course of Otenaproxesul at 150 mg PO daily is ready to go with supporting AME data.  Post-op mild LTE vs. GI ulcers, no one cares about 3-5x LTE in small subset especially when self-limiting because bigger concern is post-op DVT prophylaxis (particularly orthopedic surgeries) where incremental risk of GI bleeding with NSAIDs + DVT prophylaxis is a far worse outcome, and stopping prophylaxis due to bleeding is even worse.

Fast-track Otenaproxesul as a GI-safe opioid-sparring agent for mild-to-moderate post-operative pain as a preventative strategy for opioid addiction.

Once it's on the market, all subsequent INDs/CTAs will go faster.  Overall this is a much better drug developement strategy imho.  GLTA.

[Amigo11]

You laid it  out  there just perfectly.It's $2.00 underwater but tax selling is upon us.No obvious catalysts near term so I d expect some pressure on the price .

[mstrmnd]

4 drugs: 1. Otenaproxesul (ATB-346): Primary Indication: Post-Operative Pain Short-term use as analgesic without GI-bleeding or addictive properties.   KPI: Time-to market in Canada/US (then go off-label)  2. ATB-352 Primary Indication: TBD 3. ATB-429 Primary Indication: Mild-to-Moderae Inflammatory Bowel Disease Biological-sparring new oral treatment. 4. ATB-340 Primary

[Layth1990]

Be realistic. If H2S is toxic , then all the platform is worthless .  Do not give false hopes to anyone. People got f*cked up here, leave them alone. 

[sidtheritz]

This is exactly what i've been wondering and would apprecaite some insight on this. Isn't the whole pipeline at risk now? 

[themagicbox]

You're making a huge assumption re H2S's effect on the liver. The supposed toxicity you;'re alluding to is elevated LTEs, which is a class issue with NSAIDs and indeed ALL other medications on a longer time horizon. So H2S is not at play here.  In fact H2S has been shown to protect the liver through various mechanisms such as: -fatty acid oxidation -mitochondrial bioenrgetics in

[Layth1990]

Protect and yet we got thrown out of AME for having high LTE. The rate is higher than regular nsaids. If it is protective as what you are claiming we would have lower LTEs than other nsaids. Don'y give false hope to people 

[mstrmnd]

My take is it's on par with other NSAIDS.  In fact from an API perspective, it's less NSAID being ingested. Why are LTE's occurring then?  H2S may be inhibiting cytochrome p450 enzymes responsible for NSAID metabolism therefore reduced clearance of metabolites through kidneys in long-term use.   Since dose-dependence has been confirmed, the dose needs to be

[Rawrasaurus]

Mstrmind, I'll look it up but there is parti cyp 450 inhibition. I mentioned it in ceo but I believe it is the c9 pathway (don't quote me til I find the study). It almost certainly is building up due to his inhibition, but can also almost certainly be corrected by dropping the dose and requiring a longer ramp up time before we see clinical significance. From a clinical use, I could see

[mstrmnd]

Yes, completely agree.  This was briefly discussed at the AGM as well by Stauffer although at that time awaiting biomarker confirmation.  150 mg x 90 days will not work due to p450 inhibition.  Loading could work although challenging for OTC marketing.   150 mg x 14 days works despite p450 inhibition, both safe and effective, hence new strategy. The answer for chronic

[themagicbox]

I doubt they would go with  dosing regimen (Q8H) as part of their differentiation strategy was being "a once a day pill".  Ill say that their research into selecting a different moiety besides TBZ will be a major factor in keeping that OD differentiation. 

[mstrmnd]

Fair.  75 mg (3 tabs) PO daily x 14 days then 25 mg PO daily x 90 days.  Problem solved. 

[mstrmnd]

H2S is not toxic, review the 2a and 2b datasets.  5/42 people with LTE when 3/42 with LTE were expected on a dose ranging AME study does not equal toxicity.  There are numerous variables at play and external factors that cannot be ruled out.  The business strategy is clear, data to support short-term or PRN use is there, why go long-term use for OA given AME findings?  That

[StockingUp21]

Did the rest of the ppl have 0 LTE Could have been everyone almost else who had 4x LTE they only tell us ones who have 5x and more. If this is what happened everything you say is useless    

[mstrmnd]

You are wrong.  There's no need to guess.  Look at the published data with higher doses.  This is what happens when your mind starts speculating in the wrong direction to a question that has an answer.   GLTA

[Inthepez]

We don’t need to be perfect. No drug on planet earth will have 0 LTE. Your stup!dity is nauseating. 

[Layth1990]

We got withdrawn but the company said it nicely. If we have same lte like other naaids. The AME would be resumed. I got out with 80% loss and wont be a sheep and believe what dan rights 

[Inthepez]

Then why are you posting about the company if you're out? The reality is these butt hurt b!tches wouldnt keep posting if they didn't see some value. Or they literally have nothing better to do than be sour on the forums.

[themagicbox]

I agree with Pez. If you're out, then be an adult and leave without spreading false info. But since a few people have laid eyes on your false claim, I'll quickly debunk it.  In this publication, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3160634/, it demonstrated the hepatotoxicity of drugs in general with a section dedicated to NSAIDs. The hepatoxicity of other NSAIDs are in

[themagicbox]

I'll also add this to info. Posted a few months back by Irishcanuk. "According to the American College of Gastroenterology, the normal value for ALT in blood for people without risk factors for liver disease ranges from 29 to 33 international units per liter (IU/L) for males and 19 to 25 IU/L for females. This value can vary depending on the lab." This would make 5x the normal

[StockingUp21]

you guys now spreading false info. If everything was this easy we should restart AME trial instead of initiate chronic baghold program

[Inthepez]

The infomartion from MB and mstrmnd matches up perfectly with the "adverse events" slide at the of the corporate presentation. https://antibethera.com/wp-content/uploads/2021/09/Antibe-Corporate-Presentation-September-2021.pdf Any other FUD you want to spread? 

[StockingUp21]

So they can resume trial. if this is simple they would respond to questions and not be hiding.

[Inthepez]

I see. you need a binary answer for your binary thinking. Best for you to message the company or even health Canada regarding their regulations and report back instead of complaining. 

[MrMugsy]

Well said Pez. Fact is ... company has some figuring out to do. In the meantime ... we're adding acute pain. We wait for more information. Some of the boys here are at least chatting it up and having a conversation. That's what this place was supposed to be. Stockings ... you're being a downer man.

[Layth1990]

No one is spreading false information but you guys. Don't  give false hope to people. Atb 346 is out and the AME is not published because it is shi*t. They only mentioned about the 5x which triggered the stop and i gairantee you everyone has elevated LTE (x2, x3,x4).  If only a couple of people has elevated lte they would not move to acute pain which is 2 weeks treatment. the stomach

[mstrmnd]

This is what the company has reported in AGM and recent release.  There's no need to speculate anything otherwise, especially negative.  The market has not responded favourably, but make no mistake Antibe has a Phase 3 drug for post-operative pain coming and osteoarthritis is still on the table, with IBD next. If you own Antibe, you own an entire drug platform including the patents

[sidtheritz]

You mention ATB has a phase 3 drug for post-op coming, what timeline are you speculating?  Don't they have to do phase 2 with post-op patients?  Thanks.

[Inthepez]

Layth hendi. I see You’re complaining here and on Facebook. You’d complain on ceo as well I’m sure but you’re probably too cheap to subscribe.  Why dont you do us all a favour and message Dan  directly and give me a piece of your mind. You might feel better. [e-mail]

[Layth1990]

Yes i am compaining and i am Layth Hendi. Am i wrong though ? I lost over 100k and lot of people got fu*cked up. At least i am being realistic and stating facts about this fu*ked up Management. 

[Inthepez]

Well Layth Hendi, enough people have responded to you and you don’t want to accept their reasoned and well referenced responses.  There is risk in any biotech. You bit off more than you could chew. Hopefully you learned your lesson. I personally think this company will be fine in the long term but you may not. But complaining and cussing out Dan won’t bring your money back. i suggest you

[StockingUp21]

you are right and can say what you want how long you want. Pez is trying to take muggus job but only half as smart and twice as angry.   

[Inthepez]

Lmao and you’re trying to take yukonjizza’s job but only half as entertaining and twice as embarrassing

[MrMugsy]

Oh I'm angry with you too Stockings - I just have to be better at controlling that anger and keep focused on the mission - some of these brawl fights can easily land me in an ugly place ... don't want to spend anymore time in Sing-Sing. : )

[StockingUp21]

I will not report this but please do not threaten me muggy  

[MrMugsy]

Why would you report me? The comment I made was about me and my issues with the referee. It had nothing to do with you. Only the part that I'm angry !