* TLT * Theralase signs SRA with UM for COVID-19 vaccine 2020-08-19 07:38 ET - News Release
Dr. Arkady Mandel reports
THERALASE SIGNS AGREEMENT WITH UNIVERSITY OF MANITOBA TO COMMENCE DEVELOPMENT OF CORONAVIRUS VACCINE AND THERAPY
Theralase Technologies Inc. has executed a sponsored research agreement (SRA) with the University of Manitoba (UM) medical microbiology department to commence development of a coronavirus vaccine and therapy utilizing Theralase's patented and proprietary PDCs. According to the SRA, UM will conduct experiments in conjunction with Theralase for the research and development of a coronavirus vaccine and therapeutic to be further evaluated in animal then human clinical testing in 2021.Image: https://www.accesswire.com/users/newswire/images/602306/a8e8ff71-0336-4306-9952-9d018e662606.png
Dr. Kevin Coombs, PhD, Professor, Department of Medical Microbiology, will lead the research for the University of Manitoba. One of Dr. Coombs' interests is the investigation of how COVID-19 impacts genes and proteins in lung cells. In addition to Theralase's anti-COVID research, Dr. Coombs will lead a multi-institutional consortium using a powerful research tool, called SomaScan, and next-generation sequencing, to rapidly determine how COVID-19 (SARS-CoV-2 coronavirus) - and a variety of other coronaviruses - affect large numbers of genes and proteins in different human cells, which are the normal target of the COVID-19 virus.
Dr Coombs stated, "I have had the opportunity to independently evaluate Theralase's PDCs, on an in-vitro pre-clinical basis, as a potential new anti-viral drug; specifically targeting COVID-19. I have completed a preliminary analysis of how they affect two enveloped viruses very similar in make-up to COVID-19; specifically H1N1 Influenza and Zika virus, and am impressed with the high efficacy kill rates, both with and without stimulation."
Dr. Coombs went on to say, "From this initial data, Theralase's PDCs have a very high anti-viral activity at a very low concentration, in the nanomolar range, even when not stimulated. It is also noteworthy that this effect was observed at concentrations well below toxicity levels observed in mammalian cells or mammalian patients; therefore, this approach would provide a very high efficacy to safety ratio. Thus, the PDCs effective concentration is comparable to, or better than, many other anti-virals that my lab has tested and this virus killing capacity is further improved when the PDC is light activated, alone or in various formulations."Image: https://www.accesswire.com/users/newswire/images/602306/0a88e1c0-c47b-4e1e-80a2-0c4e4e45b37c.png
Dr Coombs also stated "Based upon the above results, I believe further studies are strongly warranted. Theralases's PDCs show great promise as a potential therapeutic. Given the similar physicochemical properties of all enveloped viruses, including the new coronavirus SARS-CoV-2, I believe Theralase's PDCs represent an important new anti-viral technology platform and I am very interested in further exploring how these PDCs could be used against COVID-19." Dr. Coombs continued, "We are planning to use a Direct Electron Detector ("DED") enhancement to a powerful TALOS200 electron microscope, which allows multichannel, high-resolution imaging and precise compositional analysis to enable dynamic microscopy applications at sub-nanometer resolution. I will use this technology to look at structures of coronaviruses after they have been treated with Theralase's formulations for cellular destruction. I look forward to working with Dr. Arkady Mandel and the Theralase team in the development of this exciting technology."
Dr. Arkady Mandel, Chief Scientific Officer, Theralase Technologies Inc. stated. "As the deadly new coronavirus continues to spread globally, Theralase has originated and fostered development of an advanced vaccine and therapy based on standardized anti-viral approaches by optimising its PDCs and anti-cancer technology platforms to prevent and fight enveloped viruses, including coronaviruses, such as COVID-19. We are pleased to announce very promising early results of our research that has been conducted by Dr. Coombs and his team at UM. This is a global pandemic, which requires research partnerships and the combined strength of multidisciplinary teams. By joining forces with UM, Theralase believes it can develop an elegant solution that will help mitigate this threat quickly and efficiently. Data in four preclinical models in both infectious disease and oncology strongly suggests that the Theralase technology platform has flexibility and bandwidth to be clinically relevant in destruction of numerous cancers and pathogens, including enveloped viruses. Now, with a new pandemic raging, Theralase is working on the development of effective mitigation strategies for the novel coronavirus that encompasses prevention of the disease and effective treatment of patients who contract COVID-19. Working with our partners at UM, the Company looks forward to introducing this game changing technology to the world in due course."
About Theralasetrademark Technologies Inc.
Theralasetrademark is a clinical stage pharmaceutical company dedicated to the research and development of light activated Photo Dynamic Compounds and their associated drug formulations intended to safely and effectively destroy various cancers.